The effect of methylene blue treatment on aspiration pneumonia

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dc.authoridColak, Alkin/0000-0001-9103-4844
dc.authorwosidColak, Alkin/R-8739-2017
dc.contributor.authorKanter, Mehmet
dc.contributor.authorSahin, Sevtap Hekimoglu
dc.contributor.authorBasaran, Umit Nusret
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorAksu, Burhan
dc.contributor.authorErboga, Mustafa
dc.contributor.authorColak, Alkin
dc.date.accessioned2024-06-12T11:07:11Z
dc.date.available2024-06-12T11:07:11Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The study aimed to examine whether methylene blue (MB) prevents different pulmonary aspiration materials-induced lung injury in rats. Methods: The experiments were designed in 60 Sprague-Dawley rats, ranging in weight from 250-300 g, randomly allotted into one of six groups (n = 10): saline control, Biosorb Energy Plus (BIO), hydrochloric acid (HCl), saline + MB treated, BIO + MB treated, and HCl + MB treated. Saline, BIO, and HCl were injected into the lungs in a volume of 2 mL/kg. After surgical procedure, MB was administered intraperitoneally for 7 days at a daily dose of 2 mg/kg per day. Seven days later, rats were killed, and both lungs in all groups were examined biochemically and histopathologically. Results: Our findings show that MB inhibits the inflammatory response reducing significantly (P < 0.05) peribronchial inflammatory cell infiltration, alveolar septal infiltration, alveolar edema, alveolar exudate, alveolar histiocytes, interstitial fibrosis, granuloma, and necrosis formation in different pulmonary aspiration models. Pulmonary aspiration significantly increased the tissue hydroxyproline content, malondialdehyde levels, and decreased (P < 0.05) the antioxidant enzyme (superoxide dismutase and glutathione peroxidase) activities. MB treatment significantly (P < 0.05) decreased the elevated tissue hydroxyproline content and malondialdehyde levels and prevented the inhibition of superoxide dismutase and glutathione peroxidase (P < 0.05) enzymes in the tissues. Furthermore, there is a significant reduction in the activity of inducible nitric oxide synthase (iNOS), terminal deoxynucleotidyl transferase dUTP nick end labeling, and arise in the expression of surfactant protein D in lung tissue of different pulmonary aspiration models with MB therapy. Conclusions: MB treatment might be beneficial in lung injury and therefore shows potential for clinical use. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2014.08.039
dc.identifier.endpage919en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue2en_US
dc.identifier.pmid25260956en_US
dc.identifier.scopus2-s2.0-84916908884en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage909en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2014.08.039
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21945
dc.identifier.volume193en_US
dc.identifier.wosWOS:000346244300051en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal Of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInosen_US
dc.subjectMethylene Blueen_US
dc.subjectPulmonary Aspirationen_US
dc.subjectSurfactant Protein Den_US
dc.subjectTUNELen_US
dc.subjectRespiratory-Distress-Syndromeen_US
dc.subjectInduced Lung Injuryen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectSurfactant Protein-Den_US
dc.subjectDetecting Pulmonary Aspirationen_US
dc.subjectAcid Aspirationen_US
dc.subjectTracheobronchial Aspirationen_US
dc.subjectReperfusion Injuryen_US
dc.subjectFeeding Aspirationen_US
dc.subjectEnteral Solutionsen_US
dc.titleThe effect of methylene blue treatment on aspiration pneumoniaen_US
dc.typeArticleen_US

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