A New Hypothesis on the Frequency Discrimination of the Cochlea

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dc.authoridUZUN, CEM/0000-0003-3233-7049
dc.authorid, erdogan/0000-0003-2036-6870
dc.authorwosidARBAK, SERAP/D-5380-2015
dc.authorwosidUZUN, CEM/K-3307-2012
dc.authorwosid, erdogan/C-4135-2015
dc.contributor.authorBulut, Erdogan
dc.contributor.authorUzun, Cem
dc.contributor.authorOzturk, Levent
dc.contributor.authorTuran, Pinar
dc.contributor.authorKanter, Mehmet
dc.contributor.authorArbak, Serap
dc.date.accessioned2024-06-12T11:00:08Z
dc.date.available2024-06-12T11:00:08Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: Medial olivocochlear efferent (MOCE) neurons innervate outer hair cells (OHCs) of the cochlea, which in turn leads to basilar membrane motion. We hypothesized that MOCE-induced alterations in basilar membrane motion, independent of traveling waves, is responsible for the cochlear frequency discrimination of sound. MATERIALS and METHODS: Eleven guinea pigs underwent bilateral otoscopic and audiologic evaluations under general anesthesia. The study comprised two parts. Part I (n=11) included spontaneous otoacoustic emission (SOAE) recordings with or without contralateral pure-tone acoustic stimuli (1 and 8 kHz) at 60 dB sound pressure level (SPL). Part II involved pure-tone (1 or 8 kHz) acoustic trauma in the right ears of two randomly selected subgroups (G1: 1 kHz; n=4 and G8: 8 kHz; n=4). The remaining three animals served as controls. After frequency-specific deafness was confirmed by distortion product otoacoustic emission (DPOAE), SOAEs were recorded in the left ears in the presence of a contralateral pure-tone (1 and 8 kHz) stimulus of 60 dB SPL. Furthermore, the surface of the organ of Corti was examined by scanning electron microscopy (SEM). RESULTS: The contralateral pure tone led to frequency-specific activation in SOAEs in part I (without trauma) and part II (with trauma) measurements. SEM showed heterogeneous OHC damage along the cochlea in traumatized ears with pure tone. CONCLUSION: We suggest that MOCEs convey acoustic information from traumatized ears to intact ears. Traumatized ears can show frequency-specific activation in the presence of diffuse damage in OHCs that excludes the passive transmission of the pressure wave from the perilymph to the basilar membrane.en_US
dc.description.sponsorshipTrakya University Unit of Scientific Research Projects (TUBAP) [902]en_US
dc.description.sponsorshipThe authors declared that this study received financial support from Trakya University Unit of Scientific Research Projects (TUBAP Nr: 902).en_US
dc.identifier.doi10.5152/iao.2017.2027
dc.identifier.endpage210en_US
dc.identifier.issn1308-7649
dc.identifier.issn2148-3817
dc.identifier.issue2en_US
dc.identifier.pmid28414275en_US
dc.identifier.scopus2-s2.0-85030784305en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.5152/iao.2017.2027
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20702
dc.identifier.volume13en_US
dc.identifier.wosWOS:000408247500011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofJournal Of International Advanced Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEfferent Pathwaysen_US
dc.subjectCochlear Outer Hair Cellsen_US
dc.subjectOtoacoustic Emissionsen_US
dc.subjectSpontaneousen_US
dc.subjectBasilar Membraneen_US
dc.subjectMicroscopyen_US
dc.subjectElectronen_US
dc.subjectScanningen_US
dc.subjectOuter Hair Cellen_US
dc.subjectPrestinen_US
dc.subjectAmplificationen_US
dc.subjectFlowen_US
dc.titleA New Hypothesis on the Frequency Discrimination of the Cochleaen_US
dc.typeArticleen_US

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