Naringin protects viscera from ischemia/reperfusion injury by regulating the nitric oxide level in a rat model

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dc.authoridUlucam, Enis/0000-0002-4686-7350
dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042
dc.authoridSanal, Filiz/0000-0002-5830-4811
dc.authorwosidUlucam, Enis/AAG-9204-2019
dc.authorwosidBAKAR, Elvan/AAE-9247-2022
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.authorwosidUluçam, Enis/HQZ-3831-2023
dc.authorwosidSanal, Filiz/O-9428-2019
dc.contributor.authorCerkezkayabekir, A.
dc.contributor.authorSanal, F.
dc.contributor.authorBakar, E.
dc.contributor.authorUlucam, E.
dc.contributor.authorInan, M.
dc.date.accessioned2024-06-12T10:52:29Z
dc.date.available2024-06-12T10:52:29Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated the effects of naringin on small intestine, liver, kidney and lung recovery after ischemia/reperfusion (I/R) injury of the gut. Rats were divided randomly into four groups of eight. Group A was the sham control; group B was ischemic for 2 h; group C was ischemic for 2 h and re-perfused for 2 h (I/R); group D was treated with 50 mg/kg naringin after ischemia, then re-perfused for 2 h. Endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) expressions were detected by immunolabeling. We also measured arginase activity, amounts of nitric oxide (NO) and total protein. iNOS was increased significantly in the small intestine, liver and kidney in group C. iNOS was decreased significantly only in small intestine and lung in group D. eNOS was increased significantly in the small intestine, liver and lung in group C. eNOS was decreased in small intestine, liver and lung in group D; however, eNOS was decreased in the kidney in group C and increased in the kidney in group D. The amount of NO was decreased significantly in all tissues in group D, but arginase activity was decreased in the small intestine and lung, increased in the kidney and remained unchanged in the liver in group D. The total protein increased in the small intestine and liver in group D, but decreased significantly in the kidney and lung in group D. Naringin had significant, salutary effects on the biochemical parameters of I/R by decreasing the NO level, equilibrating iNOS and eNOS expressions, and decreasing arginase activity.en_US
dc.description.sponsorshipTrakya University Research Center [2010-156]en_US
dc.description.sponsorshipThe authors are grateful to the Trakya University Research Center for their financial support for this study (Project no. 2010-156).en_US
dc.identifier.doi10.1080/10520295.2017.1305499
dc.identifier.endpage263en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid28426254en_US
dc.identifier.scopus2-s2.0-85018515666en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage252en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2017.1305499
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18719
dc.identifier.volume92en_US
dc.identifier.wosWOS:000401560000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArginaseen_US
dc.subjectEnosen_US
dc.subjectInosen_US
dc.subjectIschemiaen_US
dc.subjectNaringinen_US
dc.subjectNitric Oxideen_US
dc.subjectReperfusionen_US
dc.subjectIntestinal Ischemia-Reperfusionen_US
dc.subjectInduced Renal Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectInduced Neurotoxicityen_US
dc.subjectArginase Activityen_US
dc.subjectInhibitionen_US
dc.subjectDamageen_US
dc.subjectPeroxynitriteen_US
dc.subjectCytotoxicityen_US
dc.subjectSuperoxideen_US
dc.titleNaringin protects viscera from ischemia/reperfusion injury by regulating the nitric oxide level in a rat modelen_US
dc.typeArticleen_US

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