In vitro effects of L-carnitine on coronary artery bypass grafts

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dc.authoridGUCLU, Orkut/0000-0001-6460-3175
dc.authoridYuksel, Volkan/0000-0001-9518-2588
dc.authoridHuseyin, Serhat/0000-0003-4118-040X
dc.authorwosidGUCLU, Orkut/H-9993-2014
dc.contributor.authorGuclu, Orkut
dc.contributor.authorYuksel, Volkan
dc.contributor.authorHuseyin, Serhat
dc.contributor.authorEge, Turan
dc.contributor.authorCanbaz, Suat
dc.contributor.authorSungun, Mutasim
dc.date.accessioned2024-06-12T10:58:35Z
dc.date.available2024-06-12T10:58:35Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND: The gold standard treatment for multivessel coronary revascularization is coronary artery bypass grafting. The internal mammary artery and saphenous vein grafts are the conduits most frequently used for these operations. Spasm of arterial and venous grafts is a significant problem during the operation. OBJECTIVES: To evaluate the acute in vitro effects of L-carnitine on internal mammary artery and saphenous vein grafts using a tissue bath. METHODS: Ten consecutive patients who underwent elective coronary artery bypass grafting were enrolled in the present study (nine men, one woman; mean [+/- SD] age 62 +/- 9.1 years). Samples from left internal mammary artery and saphenous vein grafts were collected from each patient. Submaximal smooth muscle contraction was achieved by adding 1 mu M phenylephrine, and L-carnitine was then added to the solution. The concentration-response curves of the vasodilation response were obtained. RESULTS: In the internal mammary graft samples, the vasodilation response to L-carnitine was 64.3 +/- 11.1% at a concentration of 5 mM. In the saphenous vein graft samples, the vasodilation response to L-carnitine was 41.5 +/- 11.4% at a concentration of 5 mM. There was a statistically significant difference (P<0.001) between the response of the internal mammary artery and saphenous vein grafts in the in vitro tissue bath system. CONCLUSIONS: These results indicate that L-carnitine is a potential vasodilatory drug for internal mammary artery and saphenous vein grafts.en_US
dc.identifier.endpage120en_US
dc.identifier.issn1205-6626
dc.identifier.issue2en_US
dc.identifier.pmid23940435en_US
dc.identifier.scopus2-s2.0-84879916939en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage118en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20119
dc.identifier.volume18en_US
dc.identifier.wosWOS:000322439400025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPulsus Group Incen_US
dc.relation.ispartofExperimental & Clinical Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Artery Bypassen_US
dc.subjectInternal Mammary Arteryen_US
dc.subjectL-Carnitineen_US
dc.subjectSaphenous Veinen_US
dc.subjectPropionyl-L-Carnitineen_US
dc.subjectSaphenous-Vein Graftsen_US
dc.subjectDiseaseen_US
dc.subjectDerivativesen_US
dc.subjectRatsen_US
dc.subjectNoen_US
dc.titleIn vitro effects of L-carnitine on coronary artery bypass graftsen_US
dc.typeArticleen_US

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