Comparative Investigation of Anti-Inflammatory Effect of Platelet-Rich Fibrin after Mandibular Wisdom Tooth Surgery: A Randomized Controlled Study

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dc.contributor.authorKaraca, Gamze Tanan
dc.contributor.authorDuygu, Gonca
dc.contributor.authorEr, Nilay
dc.contributor.authorOzgun, Eray
dc.date.accessioned2024-06-12T10:51:59Z
dc.date.available2024-06-12T10:51:59Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters. Forty-eight patients with impacted wisdom teeth in bilateral and similar positions were included in the study. The control group was formed with the standard surgery and the PRF group was formed with local PRF application in addition to standard procedure (n = 96). The anti-inflammatory activity of PRF on postoperative 2nd and 7th days was evaluated subjectively by clinical parameters and objectively by biochemical parameters. Postoperative 2nd- and 7th-day follow-up data of pain, edema, and trismus in the PRF group were found to be statistically significantly lower. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were found to be statistically significantly lower in the PRF group than the control in the postoperative 2nd-day follow-up period (p < 0.001). There was no statistically significant difference in interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-& alpha;) parameters when the PRF group and the control group were compared in both follow-up periods (p > 0.05). The study has demonstrated the effectiveness of locally applied PRF after ITM surgery via clinical parameters and objective data. The quantitative analysis of CRP and ERS can be an effective parameter in determining the amount of inflammation after ITM surgery.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Department [2019/235]en_US
dc.description.sponsorshipThis study was funded by the Trakya University Scientific Research Projects Department by the number 2019/235.en_US
dc.identifier.doi10.3390/jcm12134250
dc.identifier.issn2077-0383
dc.identifier.issue13en_US
dc.identifier.pmid37445285en_US
dc.identifier.scopus2-s2.0-85165020166en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcm12134250
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18561
dc.identifier.volume12en_US
dc.identifier.wosWOS:001028570300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal Of Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-Inflammatory Effecten_US
dc.subjectEdemaen_US
dc.subjectSerum Markersen_US
dc.subjectPRFen_US
dc.subjectWisdom Toothen_US
dc.subject3rd Molar Surgeryen_US
dc.subjectPostoperative Complicationsen_US
dc.subjectTnf-Alphaen_US
dc.subjectPainen_US
dc.subjectExtractionen_US
dc.subjectEfficacyen_US
dc.subjectTrismusen_US
dc.subjectMethylprednisoloneen_US
dc.subjectDexamethasoneen_US
dc.subjectCrpen_US
dc.titleComparative Investigation of Anti-Inflammatory Effect of Platelet-Rich Fibrin after Mandibular Wisdom Tooth Surgery: A Randomized Controlled Studyen_US
dc.typeArticleen_US

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