Mucins, trefoil factors and pancreatic duodenal homeobox 1 expression in spasmolytic polypeptide expressing metaplasia and intestinal metaplasia adjacent to gastric carcinomas

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dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authorwosidTokuç, Burcu/ABF-7730-2021
dc.authorwosidOzyilmaz, Filiz/A-4865-2016
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.contributor.authorCan, Nuray
dc.contributor.authorPuyan, Fulya Oz
dc.contributor.authorAltaner, Semsi
dc.contributor.authorOzyilmaz, Filiz
dc.contributor.authorTokuc, Burcu
dc.contributor.authorPehlivanoglu, Zeynep
dc.contributor.authorKutlu, Kemal Ali
dc.date.accessioned2024-06-12T11:15:25Z
dc.date.available2024-06-12T11:15:25Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: Gastric cancers are the second cause of cancer related deaths all around the world but gastric carcinogenesis remains a mystery. Intestinal metaplasia (IM) and spasmolytic polypeptide expressing metaplasia (SPEM) are the two types of preneoplastic metaplasias. In this study, we aimed to investigate expression of Pancreatic duodenal homeobox 1 (PDX1), mucins (MUCs), trefoil factors (TFFs) in SPEM and IM surrounding gastric carcinomas. Material and methods: Tissue samples of tumor adjacent gastric mucosa including IM (n = 61) and SPEM (n = 36) from 70 gastrectomy specimens were used for immunohistochemical analysis of PDX1, mucins (MUC5AC, MUC6) and trefoil factors (TFF2, TFF3). Results: Nuclear expression of PDX1 was present in both SPEM (32/36) and IM (60/61) and there was no significant difference in expression of PDX1 between the two types of metaplasias. While TFF3 and MUC5AC were abundant in IM, SPEM showed 100% expression of TFF2 and MUC6 and also lower positivity with TFF3 and MUC5AC. PDX1 positivity was related to expression of MUC5AC (60/61, p < 0.001) and TFF3 (60/61, p < 0.001) in IM and also associated with expression of MUC5AC (14/32, p < 0.05), MUC6 (32/32, p < 0.001), TFF2 (32/32, p < 0.001) and TFF3 (9/32, p < 0.05) in SPEM. Coexpression of TFF3 and TFF2 was present in 10 of 36 (27.7%) samples of SPEM and also 29 of 61 (47.5%) samples of IM exhibited dual expression of trefoil peptides. Conclusions: PDX1 may affect the development of SPEM and IM. Expression patterns of TFFs and MUCs may indicate that IM evolves from SPEM.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects (TUBAP) [110/08]en_US
dc.description.sponsorshipThis work was supported by Trakya University Scientific Research Projects (TUBAP), No. 110/08.en_US
dc.identifier.doi10.5114/aoms.2013.36923
dc.identifier.endpage1410en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue6en_US
dc.identifier.pmid33224340en_US
dc.identifier.scopus2-s2.0-85013076322en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1402en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2013.36923
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23931
dc.identifier.volume16en_US
dc.identifier.wosWOS:000585918400016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpasmolytic Polypeptide Expressing Metaplasiaen_US
dc.subjectIntestinal Metaplasiaen_US
dc.subjectTrefoil Factorsen_US
dc.subjectPancreatic Duodenal Homeobox 1en_US
dc.subjectMucinsen_US
dc.subjectOxyntic Atrophyen_US
dc.subjectCell Lineageen_US
dc.subjectCanceren_US
dc.subjectIdentificationen_US
dc.subjectSpemen_US
dc.subjectCarcinogenesisen_US
dc.subjectInductionen_US
dc.subjectPeptidesen_US
dc.subjectPdx1en_US
dc.subjectCdx2en_US
dc.titleMucins, trefoil factors and pancreatic duodenal homeobox 1 expression in spasmolytic polypeptide expressing metaplasia and intestinal metaplasia adjacent to gastric carcinomasen_US
dc.typeArticleen_US

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