Effects of hyperthyroidism on expression of vascular endothelial growth factor (VEGF) and apoptosis in fetal adrenal glands

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dc.authoridKARACA, Turan/0000-0002-2500-7781;
dc.authorwosidkaraboga, ihsan/AAZ-9840-2020
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidÇİÇEK, Ayşegül ÇOPUR/AAM-6146-2021
dc.authorwosiddemirtaş, selim/JED-6784-2023
dc.contributor.authorKaraca, T.
dc.contributor.authorUz, Y. Hulya
dc.contributor.authorKarabacak, R.
dc.contributor.authorKaraboga, I.
dc.contributor.authorDemirtas, S.
dc.contributor.authorCicek, A. Cagatay
dc.date.accessioned2024-06-12T11:03:36Z
dc.date.available2024-06-12T11:03:36Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study investigated the expression of vascular endothelial growth factor (VEGF), vascular density and apoptosis in fetal rat adrenal glands with hyperthyroidism in late gestation. Twelve mature female Wistar albino rats with the same biological and physiological features were used for this study. Rats were divided into two groups: control and hyperthyroidism. Hyperthyroidism was induced by daily subcutaneous injections of L-thyroxine (250 mu g/kg) before pregnancy for 21 days and during pregnancy Rats in the control and hyperthyroidism groups were caged according to the number of male rats. Zero day of pregnancy (Day 0) was indicated when the animals were observed to have microscopic sperm in vaginal smears. Pregnant rats were sacrificed on the 20th day of pregnancy; blood from each animal was collected to determine the concentrations of maternal adrenocorticotropic hormone and thyroxine. Rat fetuses were then quickly removed from the uterus, and the adrenal glands of the fetuses were dissected. VEGF expression, vascular density and apoptosis were analyzed in fetal rat adrenal glands. Maternal serum levels of the ACTH and free thyroxine were significantly higher in the hyperthyroidism group than in the control group. Immunohistochemistry revealed that the number of VEGF positive cells and vessel density significantly increased in the hyperthyroidism rat fetal adrenal group compared with the control group. Hyperthyroidism did not change the fetal and placental weights and the number of fetuses. This study demonstrates that hyperthyroidism may have an effect on the development of rat adrenal glands mediated by VEGF expression, angiogenesis, and apoptosis.en_US
dc.identifier.doi10.4081/ejh.2015.2560
dc.identifier.endpage262en_US
dc.identifier.issn1121-760X
dc.identifier.issn2038-8306
dc.identifier.issue4en_US
dc.identifier.pmid26708182en_US
dc.identifier.scopus2-s2.0-84948984693en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage258en_US
dc.identifier.urihttps://doi.org/10.4081/ejh.2015.2560
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21714
dc.identifier.volume59en_US
dc.identifier.wosWOS:000367451600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPagepress Publen_US
dc.relation.ispartofEuropean Journal Of Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyperthyroidismen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.subjectVessel Densityen_US
dc.subjectFetal Adrenalen_US
dc.subjectRaten_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectCortexen_US
dc.subjectCellsen_US
dc.subjectAngiogenesisen_US
dc.subjectTransductionen_US
dc.subjectRatsen_US
dc.titleEffects of hyperthyroidism on expression of vascular endothelial growth factor (VEGF) and apoptosis in fetal adrenal glandsen_US
dc.typeArticleen_US

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