The relationship between prognostic nutritional index and treatment response in patients with metastatic renal cell cancer

Basit Öğe Kaydı
dc.authoridYaşar, Hatime Arzu/0000-0002-0545-1383
dc.authoridbilgin, burak/0000-0003-1717-8246
dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authoridÜrün, Yüksel/0000-0002-9152-9887
dc.authoridKilickap, Saadettin/0000-0003-1637-7390
dc.authoridErturk, Ismail/0000-0001-6835-0988
dc.authoridUcar, Gokhan/0000-0002-7649-1075;
dc.authorwosidYaşar, Hatime Arzu/HGC-5631-2022
dc.authorwosidbilgin, burak/A-9416-2018
dc.authorwosidCicin, Irfan/AAQ-5575-2020
dc.authorwosidSendur, Mehmet Ali Nahit/H-7555-2014
dc.authorwosidÜrün, Yüksel/AAQ-3612-2020
dc.authorwosidbir yucel, kadriye/HGE-4410-2022
dc.authorwosidKüçükarda, Ahmet/AGF-2120-2022
dc.contributor.authorYasar, Hatime Arzu
dc.contributor.authorYucel, Kadriye Bir
dc.contributor.authorArslan, Cagatay
dc.contributor.authorUcar, Gokhan
dc.contributor.authorKarakaya, Serdar
dc.contributor.authorBilgin, Burak
dc.contributor.authorTaban, Hakan
dc.date.accessioned2024-06-12T11:12:56Z
dc.date.available2024-06-12T11:12:56Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction and aim To investigate the effect of the prognostic nutritional index on treatment response and survival in patients with metastatic renal cell cancer. Methods We retrospectively analyzed the treatment modalities; the demographic, clinical and pathological features of 396 patients with RCC and prognostic nutritional index. Based on the median value, patients were grouped as having low and high prognostic nutritional index values. Kaplan-Meier method was used for survival analysis, and Cox-regression analysis was used for multivariate analysis. Results The median overall survival was 39 months (95% CI 26.1-51.8), 28 months (95% CI 17.9-38) and 7 months (95% CI 4.7-9.2) in patients with favorable, intermediate and poor International Metastatic Renal Cell Carcinoma Database Consortium risk group, respectively. The difference between the groups was statistically significant (p < 0001). Overall survival was 11 months (95% CI 7.5-14.5) in the low-prognostic nutritional index (prognostic nutritional index <= 38.5) group, and 41 months (95% CI 30.5-51.4) in the high prognostic nutritional index (prognostic nutritional index >38.5) group (p < 0.001). In Cox regression analysis, Eastern Cooperative Oncology Group performance score (HR: 2.5), time to systemic treatment (HR: 1.7) and prognostic nutritional index (HR: 1.8) were associated with overall survival. Conclusion In patients with renal cell cancer, prognostic nutritional index is closely related to survival and has prognostic significance.en_US
dc.identifier.doi10.1177/1078155219883004
dc.identifier.endpage1116en_US
dc.identifier.issn1078-1552
dc.identifier.issn1477-092X
dc.identifier.issue5en_US
dc.identifier.pmid31653193en_US
dc.identifier.scopus2-s2.0-85076539078en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1110en_US
dc.identifier.urihttps://doi.org/10.1177/1078155219883004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23365
dc.identifier.volume26en_US
dc.identifier.wosWOS:000492665900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of Oncology Pharmacy Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrognostic Nutritional Indexen_US
dc.subjectRenal Cell Carcinomaen_US
dc.subjectTyrosine Kinase Inhibitoren_US
dc.subjectPrognosisen_US
dc.subjectLymphocyte Ratioen_US
dc.subjectInterferon-Alphaen_US
dc.subjectCarcinomaen_US
dc.subjectPredictoren_US
dc.subjectSunitiniben_US
dc.subjectPazopaniben_US
dc.subjectSurvivalen_US
dc.subjectScoresen_US
dc.titleThe relationship between prognostic nutritional index and treatment response in patients with metastatic renal cell canceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu