The effects of methylene blue on renal scarring due to pyelonephritis in rats

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dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridGurcan, Saban/0000-0002-5052-481X
dc.authoridUzun, Hafize/0000-0002-1347-8498
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidaydın, seval/AAD-3579-2021
dc.authorwosidGurcan, Saban/D-2754-2017
dc.authorwosidUzun, Hafize/D-4811-2019
dc.contributor.authorAksu, Burhan
dc.contributor.authorInan, Mustafa
dc.contributor.authorKanter, Mehmet
dc.contributor.authorPuyan, Fulya Oz
dc.contributor.authorUzun, Hafize
dc.contributor.authorDurmus-Altun, Gulay
dc.contributor.authorGurcan, Saban
dc.date.accessioned2024-06-12T11:13:10Z
dc.date.available2024-06-12T11:13:10Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the efficiency of methylene blue (MB) in preventing renal scar formation after the induction of pyelonephritis (PNP) in a rat model with delayed antimicrobial therapy. An inoculum of the K-12 strain of Escherichia coli was injected into both kidneys. Control groups received isotonic saline instead of bacterial solution. Four equal groups were then formed: the PNP group was untreated and the PNP ciprofloxacin (CIP) treated group was treated only with CIP intraperitoneally (i.p.) starting on the third day following bacterial inoculation. In the PNP (MB)-treated group, MB was given i.p., and in the PNP MB + CIP-treated group, MB + CIP were administered i.p.. In the sixth week following bacterial inoculation, all rats were sacrificed, and both kidneys of the rats in all groups were examined biochemically and histopathologically for renal scarring. Renal scar was significant in the groups treated with MB alone or MB + CIP combination compared with untreated or antibiotic only groups. Delayed treatment with antibiotics had no effect on scarring. These results suggest that the addition of MB to the delayed antibiotic therapy might be beneficial in preventing PNP-induced oxidative renal tissue damage.en_US
dc.identifier.doi10.1007/s00467-007-0464-8
dc.identifier.endpage1001en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue7en_US
dc.identifier.pmid17390153en_US
dc.identifier.scopus2-s2.0-34250021645en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage992en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-007-0464-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23453
dc.identifier.volume22en_US
dc.identifier.wosWOS:000247310100011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPyelonephritisen_US
dc.subjectRenal Scarringen_US
dc.subjectOxidative Damageen_US
dc.subjectMethylene Blueen_US
dc.subjectCiprofloxacinen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectAscending Mouse Modelen_US
dc.subjectEscherichia-Colien_US
dc.subjectVesicoureteral Refluxen_US
dc.subjectTissue-Injuryen_US
dc.subjectRelaxing Factoren_US
dc.subjectInfectionen_US
dc.subjectSuppressionen_US
dc.subjectGenerationen_US
dc.subjectPreventionen_US
dc.titleThe effects of methylene blue on renal scarring due to pyelonephritis in ratsen_US
dc.typeArticleen_US

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