Low sCD163/TWEAK Ratio at First Day After Acute Myocardial Infarction Associated with Adverse Cardiac Remodeling in Non-Elderly Patients

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dc.authoridKızıltunç, Emrullah/0000-0002-8152-9680
dc.authoridGök, Murat/0000-0003-3118-9064
dc.authoridkarayiğit, orhan/0000-0003-0033-4353
dc.authoridAltintas, Mehmet sait/0000-0001-8206-8268
dc.authoridDemirtaş, Bekir/0000-0002-6266-2291
dc.authorideyerci, Nilnur/0000-0002-6293-3338
dc.authorwosidKızıltunç, Emrullah/AAQ-3582-2020
dc.authorwosidGök, Murat/AAZ-3324-2021
dc.authorwosidkarayiğit, orhan/HOC-0196-2023
dc.authorwosidAltintas, Mehmet sait/HSC-9027-2023
dc.authorwosidDemirtaş, Bekir/GRJ-5653-2022
dc.contributor.authorAltintas, Mehmet Sait
dc.contributor.authorEyerci, Nilnur
dc.contributor.authorKarayigit, Orhan
dc.contributor.authorDemirtas, Bekir
dc.contributor.authorGok, Murat
dc.contributor.authorKiziltunc, Emrullah
dc.date.accessioned2024-06-12T11:03:51Z
dc.date.available2024-06-12T11:03:51Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim In this study, we aimed to investigate the role of sCD163 /tumor necrosis factor-like weak apoptosisinducing (TWEAK) ratio in cardiac remodeling in non-elderly patients diagnosed with first acute myocardial infarction (MI). Material and Methods Forty-four patients (age ranges: 40-64 years) diagnosed with first-time acute ST-elevation MI in the emergency department were evaluated with cardiac magnetic resonance (CMR) imaging. Adverse remodeling (AR) was defined the increases of left ventricular end-diastolic volume by =12 % by CMR at 6-month post-MI TWEAK and sCD163 were measured at the first day (baseline), 2 weeks and 6 weeks post-MI. Results The average age of patients included in the study was 53.6 +/- 5.1 years. AR was detected in 18 patients at the 6 months post-MI. At the first day post-MI, median sCD163 concentration (116 069 vs 86 394 pg/ mL, p=0.040) and median TWEAK concentration (759.4 vs 220.1 pg /mL, p<0.001) were higher in AR group compared to group without AR (the non-AR group), median sCD163 /TWEAK ratio (101.4 vs. 406.8; p<0.001) was lower. At the first day post-MI, concentrations of TWEAK and sCD163 showed a positive correlation in AR group and group without AR s. At 2 weeks post-MI, positive correlation continued in the non-AR group, but no significant correlation was found in the AR group. At the first day post-MI, sCD163/TWEAK ratio was higher diagnostic performance compared to TWEAK and sCD163. Conclusion In the early phase post-MI, the relationship between sCD163 - TWEAK may have an important role in AR pathogenesis. A lower sCD163 /TWEAK ratio on the first day after MI was associated with an increase in left ventricular end-diastolic volume after 6 months of follow-up.en_US
dc.description.sponsorshipMinistry of Health of the Republic of Turkey (Department Of Research, Development And Health Technology Evaluation) [2015/SAGEM-2/001]en_US
dc.description.sponsorshipThe authors declared that this research received financial support from The Ministry of Health of the Republic of Turkey (Department Of Research, Development And Health Technology Evaluation) 2015/SAGEM-2/001 project.en_US
dc.identifier.doi10.18087/cardio.2022.10.n2155
dc.identifier.endpage55en_US
dc.identifier.issn0022-9040
dc.identifier.issue10en_US
dc.identifier.pmid36384409en_US
dc.identifier.scopus2-s2.0-85142140187en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://doi.org/10.18087/cardio.2022.10.n2155
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21798
dc.identifier.volume62en_US
dc.identifier.wosWOS:000898637700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRussian Heart Failure Socen_US
dc.relation.ispartofKardiologiyaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectScd163en_US
dc.subjectMyocardial Infarctionen_US
dc.subjectTWEAKen_US
dc.subjectCardiac Remodelingen_US
dc.subjectSoluble Tweaken_US
dc.titleLow sCD163/TWEAK Ratio at First Day After Acute Myocardial Infarction Associated with Adverse Cardiac Remodeling in Non-Elderly Patientsen_US
dc.typeArticleen_US

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