Low sCD163/TWEAK Ratio at First Day After Acute Myocardial Infarction Associated with Adverse Cardiac Remodeling in Non-Elderly Patients
dc.authorid | Kızıltunç, Emrullah/0000-0002-8152-9680 | |
dc.authorid | Gök, Murat/0000-0003-3118-9064 | |
dc.authorid | karayiğit, orhan/0000-0003-0033-4353 | |
dc.authorid | Altintas, Mehmet sait/0000-0001-8206-8268 | |
dc.authorid | Demirtaş, Bekir/0000-0002-6266-2291 | |
dc.authorid | eyerci, Nilnur/0000-0002-6293-3338 | |
dc.authorwosid | Kızıltunç, Emrullah/AAQ-3582-2020 | |
dc.authorwosid | Gök, Murat/AAZ-3324-2021 | |
dc.authorwosid | karayiğit, orhan/HOC-0196-2023 | |
dc.authorwosid | Altintas, Mehmet sait/HSC-9027-2023 | |
dc.authorwosid | Demirtaş, Bekir/GRJ-5653-2022 | |
dc.contributor.author | Altintas, Mehmet Sait | |
dc.contributor.author | Eyerci, Nilnur | |
dc.contributor.author | Karayigit, Orhan | |
dc.contributor.author | Demirtas, Bekir | |
dc.contributor.author | Gok, Murat | |
dc.contributor.author | Kiziltunc, Emrullah | |
dc.date.accessioned | 2024-06-12T11:03:51Z | |
dc.date.available | 2024-06-12T11:03:51Z | |
dc.date.issued | 2022 | |
dc.department | Trakya Üniversitesi | en_US |
dc.description.abstract | Aim In this study, we aimed to investigate the role of sCD163 /tumor necrosis factor-like weak apoptosisinducing (TWEAK) ratio in cardiac remodeling in non-elderly patients diagnosed with first acute myocardial infarction (MI). Material and Methods Forty-four patients (age ranges: 40-64 years) diagnosed with first-time acute ST-elevation MI in the emergency department were evaluated with cardiac magnetic resonance (CMR) imaging. Adverse remodeling (AR) was defined the increases of left ventricular end-diastolic volume by =12 % by CMR at 6-month post-MI TWEAK and sCD163 were measured at the first day (baseline), 2 weeks and 6 weeks post-MI. Results The average age of patients included in the study was 53.6 +/- 5.1 years. AR was detected in 18 patients at the 6 months post-MI. At the first day post-MI, median sCD163 concentration (116 069 vs 86 394 pg/ mL, p=0.040) and median TWEAK concentration (759.4 vs 220.1 pg /mL, p<0.001) were higher in AR group compared to group without AR (the non-AR group), median sCD163 /TWEAK ratio (101.4 vs. 406.8; p<0.001) was lower. At the first day post-MI, concentrations of TWEAK and sCD163 showed a positive correlation in AR group and group without AR s. At 2 weeks post-MI, positive correlation continued in the non-AR group, but no significant correlation was found in the AR group. At the first day post-MI, sCD163/TWEAK ratio was higher diagnostic performance compared to TWEAK and sCD163. Conclusion In the early phase post-MI, the relationship between sCD163 - TWEAK may have an important role in AR pathogenesis. A lower sCD163 /TWEAK ratio on the first day after MI was associated with an increase in left ventricular end-diastolic volume after 6 months of follow-up. | en_US |
dc.description.sponsorship | Ministry of Health of the Republic of Turkey (Department Of Research, Development And Health Technology Evaluation) [2015/SAGEM-2/001] | en_US |
dc.description.sponsorship | The authors declared that this research received financial support from The Ministry of Health of the Republic of Turkey (Department Of Research, Development And Health Technology Evaluation) 2015/SAGEM-2/001 project. | en_US |
dc.identifier.doi | 10.18087/cardio.2022.10.n2155 | |
dc.identifier.endpage | 55 | en_US |
dc.identifier.issn | 0022-9040 | |
dc.identifier.issue | 10 | en_US |
dc.identifier.pmid | 36384409 | en_US |
dc.identifier.scopus | 2-s2.0-85142140187 | en_US |
dc.identifier.scopusquality | Q4 | en_US |
dc.identifier.startpage | 49 | en_US |
dc.identifier.uri | https://doi.org/10.18087/cardio.2022.10.n2155 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14551/21798 | |
dc.identifier.volume | 62 | en_US |
dc.identifier.wos | WOS:000898637700006 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Russian Heart Failure Soc | en_US |
dc.relation.ispartof | Kardiologiya | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Scd163 | en_US |
dc.subject | Myocardial Infarction | en_US |
dc.subject | TWEAK | en_US |
dc.subject | Cardiac Remodeling | en_US |
dc.subject | Soluble Tweak | en_US |
dc.title | Low sCD163/TWEAK Ratio at First Day After Acute Myocardial Infarction Associated with Adverse Cardiac Remodeling in Non-Elderly Patients | en_US |
dc.type | Article | en_US |