The genotoxic effects of mixture of aluminum, arsenic, cadmium, cobalt, and chromium on the gill tissue of adult zebrafish (Danio rerio, Hamilton 1822)

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dc.authoridDoganlar, Zeynep Banu/0000-0002-1365-9897
dc.authorid/0000-0003-4135-2486
dc.authoridGokalp, Fulya Dilek/0000-0001-8219-6657
dc.authorwosidDoganlar, Zeynep Banu/B-4845-2008
dc.authorwosidDoğanlar, Oğuzhan/A-2315-2019
dc.authorwosid/A-1666-2016
dc.contributor.authorGokalp, Fulya Dilek
dc.contributor.authorDoganlar, Oguzhan
dc.contributor.authorDoganlar, Zeynep Banu
dc.contributor.authorGuner, Utku
dc.date.accessioned2024-06-12T11:02:34Z
dc.date.available2024-06-12T11:02:34Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the genotoxic effects of mixtures of five metals on zebrafish at two different concentrations; at the permissible maximum contamination levels in drinking water and irrigation waters. The drinking water limits are as follows: 300 mu g/L for Aluminum (Al+3), 10 mu g/L for Arsenic (As+3), 5 mu g/L for Cadmium (Cd+2), 10 mu g/L for Cobalt (Co+2), and 50 mu g/L for Chromium (Cr+2). The irrigation water limits: 5000 mu g/L for Al+3, 100 mu g/L for As+3, 10 mu g/L for Cd+2, 50 mu g/L for Co+2, and 100 mu g/L for Cr+2. The zebrafish underwent chronic exposure for periods of 5, 10, and 20 days. The gene expressions for mitochondrial superoxide dismutase (SOD2), stress-specific receptor protein NCCRP1, the heat shock proteins: Hsp9, Hsp14, Hsp60, Hsp70, DNA repair (XRCC1 and EXO1), and apoptosis (BOK and BAX) were evaluated. It was found that exposure to the low- and high-concentrations of the heavy metal mixtures caused cell stress, an increased expression of the antioxidant genes, and repair proteins. As the duration of exposure was increased, the cells progressed through the apoptotic pathway. This was more evident in the high-concentration exposure groups. The results demonstrated the necessity for a reevaluation of the maximum values of heavy metal and toxic element concentrations as prescribed by the Local Standing Rules of Water Pollution Control Regulation, as well as a reevaluation of the limitations of heavy metal mixture interactions with respect to ecological balance and environmental health.en_US
dc.description.sponsorshipManagement Unit of Research Projects of Trakya University, Edirne, Turkey [TUBAP-2015-179]en_US
dc.description.sponsorshipThis work was supported by the Management Unit of Research Projects of Trakya University under Grant (project ID: TUBAP-2015-179), Edirne, Turkey.en_US
dc.identifier.doi10.1080/01480545.2020.1810260
dc.identifier.endpage1167en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue3en_US
dc.identifier.pmid32847431en_US
dc.identifier.scopus2-s2.0-85089897854en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1158en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1810260
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21339
dc.identifier.volume45en_US
dc.identifier.wosWOS:000566467400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug And Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenotoxicityen_US
dc.subjectMetal Mixtureen_US
dc.subjectGene Expressionen_US
dc.subjectApoptosisen_US
dc.subjectDNA Repairen_US
dc.subjectHeat Shock Proteinsen_US
dc.subjectInduced Oxidative Stressen_US
dc.subjectMessenger-Rna Expressionen_US
dc.subjectAcute Metal Exposuresen_US
dc.subjectHeavy-Metalsen_US
dc.subjectDna-Damageen_US
dc.subjectGene-Expressionen_US
dc.subjectGroundwater Contaminantsen_US
dc.subjectOccupational-Exposureen_US
dc.subjectSubchronic Exposureen_US
dc.subjectCell-Proliferationen_US
dc.titleThe genotoxic effects of mixture of aluminum, arsenic, cadmium, cobalt, and chromium on the gill tissue of adult zebrafish (Danio rerio, Hamilton 1822)en_US
dc.typeArticleen_US

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