The Protective Effect of Curcumin on Ionizing Radiation-induced Cataractogenesis in Rats

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dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorOzgen, Seher Cimen
dc.contributor.authorDokmeci, Dikmen
dc.contributor.authorAkpolat, Meryem
dc.contributor.authorKaradag, Cetin Hakan
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorErbas, Hakan
dc.contributor.authorBenian, Omer
dc.date.accessioned2024-06-12T10:55:57Z
dc.date.available2024-06-12T10:55:57Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to determine the protective effect of curcumin against ionizing radiation-induced cataract in the lens of rats. Material and Methods: Rats were divided into six groups. Group 1: Control, Group 2: Dimethyl sulfoxide (DMSO), Group 3: DMSO+curcumin, Group 4: Irradiation, Group 5: Irradiation+DMSO, Group 6: Irradiation+DMSO+curcumin. A 15 Gy total dose was given to 4, 5, 6 groups for radiation damage. Curcumin (100 mg/kg) was dissolved in DMSO and given by intragastric intubation for 28 days. At the end of the experiment, lenses were graded and enucleated. The lenticular activity of the antioxidant enzymes, total antioxidant and glutathione peroxidase (GSH-Px), and the malondialdehyde (MDA) were measured. Results: 100% Cataract was seen in the irradiation group. Cataract rate fell to 40% and was limited at grade 1 and 2 in the curcumin group. In the irradiation group, antioxidant enzyme levels were decreased, MDA levels were increased. There was an increase in antioxidant enzyme levels and a significant decrease in MDA in the group which was given curcumin. Conclusion: Curcumin has antioxidant and radioprotective properties and is likely to be a valuable agent for protection against ionizing radiation. Hence, it may be used as an antioxidant and radioprotector against radiation-induced cataractogenesis.en_US
dc.description.sponsorshipTrakya University Scientific Research Project Unit (TUBAP), Edirne, Turkeyen_US
dc.description.sponsorshipThis study was supported by the Trakya University Scientific Research Project Unit (TUBAP), Edirne, Turkey.en_US
dc.identifier.doi10.5152/balkanmedj.2012.038
dc.identifier.endpage363en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.pmid25207034en_US
dc.identifier.scopus2-s2.0-84872799905en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage358en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2012.038
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19600
dc.identifier.volume29en_US
dc.identifier.wosWOS:000315000900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCataracten_US
dc.subjectCurcuminen_US
dc.subjectIonizing Radiationen_US
dc.subjectLipid Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.subjectRadioprotectiveen_US
dc.subjectSelenite-Induced Cataractogenesisen_US
dc.subjectGinkgo-Biloba Supplementationen_US
dc.subjectInduced Oxidative Injuryen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectL-Carnitineen_US
dc.subjectChaperone Activityen_US
dc.subjectDiabetic Cataracten_US
dc.subjectGamma-Irradiationen_US
dc.subjectAlpha-Crystallinen_US
dc.subjectPreventionen_US
dc.titleThe Protective Effect of Curcumin on Ionizing Radiation-induced Cataractogenesis in Ratsen_US
dc.typeArticleen_US

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