Derivation and validation of adult Still Activity Score (SAS)

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dc.authoridYıldız, Fatih/0000-0003-3628-8870
dc.authoridKanıtez, Nilüfer Alpay/0000-0003-1185-5816
dc.authoridkucuksahin, orhan/0000-0003-4530-2304
dc.authoridBilgin, Emre/0000-0002-2260-4660
dc.authoridErden, Abdulsamet/0000-0002-8084-2018
dc.authorwosidYıldız, Fatih/P-2555-2018
dc.authorwosidKanıtez, Nilüfer Alpay/W-7332-2019
dc.authorwosidkucuksahin, orhan/GZA-3287-2022
dc.authorwosidErmurat, Selime/ABE-4424-2022
dc.authorwosidBilgin, Emre/C-8092-2015
dc.authorwosidErden, Abdulsamet/W-2397-2019
dc.contributor.authorKalyoncu, Umut
dc.contributor.authorKasifoglu, Timucin
dc.contributor.authorOmma, Ahmet
dc.contributor.authorBes, Cemal
dc.contributor.authorCinar, Muhammet
dc.contributor.authorEmmungil, Hakan
dc.contributor.authorKucuksahin, Orhan
dc.date.accessioned2024-06-12T10:50:51Z
dc.date.available2024-06-12T10:50:51Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Adult-onset Still's disease (AOSD) is a multi-systemic, autoinflammatory disorder. Several activity scores have been proposed but none of them have been adopted universally. Our aim was to create a clinician-friendly activity scoring system by using simple clinical and laboratory parameters.Methods: AODS patients, according to Yamaguchi criteria, were included in this cross-sectional, multi-center study. Derivation and validation cohorts were constituted. Demographic, clinical, and laboratory evaluation at the study visit; patients' and physicians' global assessments of disease activity (both VAS/Likert scale) were recorded. To develop the score, an ordinal logistic regression model was used to determine independent predictors of physicians' global assessments of disease activity. Clinically and statistically significant variables were weighted according to regression coefficients. Then, performance of the score was tested on the validation cohort. Results: A total of 197 consecutive AOSD patients (125 in derivation, 72 in validation cohorts) were included. Final Still Activity Score was fever (2 points), arthralgia (2 points, plus 1 point if arthritis was present in >= 2 joints), neutrophilia >= 65% (1 point) and ferritin >= 350 ng/mL (1 point) (maximum of 7 points). The SAS yielded an AUC value of 0.98 (0.96-1.00) in the derivation cohort and 0.91 (95%CI: 0.85-0.98) in the validation cohort to discriminate high AOSD activity from moderate-inactive AOSD. The correlation of SAS with PGA was 83% for the derivation cohort and 76% for the validation cohort. Conclusions: SAS has shown a good test performance to distinguish active AOSD patients from others. SAS may be a useful method for evaluating the disease activity of AOSD patients in daily practice.(c) 2022 Socie acute accent te acute accent franc , aise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.jbspin.2022.105499
dc.identifier.issn1297-319X
dc.identifier.issn1778-7254
dc.identifier.issue1en_US
dc.identifier.pmid36423781en_US
dc.identifier.scopus2-s2.0-85142832760en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jbspin.2022.105499
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18155
dc.identifier.volume90en_US
dc.identifier.wosWOS:000902129000003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofJoint Bone Spineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdult-Onset Still?S Diseaseen_US
dc.subjectDisease Activity Scoreen_US
dc.subjectArthralgiaen_US
dc.subjectFerritinen_US
dc.subjectClinical-Manifestationsen_US
dc.subjectDisease Courseen_US
dc.subjectMulticenteren_US
dc.titleDerivation and validation of adult Still Activity Score (SAS)en_US
dc.typeArticleen_US

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