Corneal epithelium and limbal region alterations due to glaucoma medications evaluated by anterior segment optic coherence tomography: a case-control study

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dc.authoridSakallıoğlu, Ahmet Kürşad/0000-0003-1206-9753
dc.authoridGUCLU, HANDE/0000-0002-3021-0493
dc.authorwosidSakallıoğlu, Ahmet Kürşad/ADG-0599-2022
dc.contributor.authorGuclu, Hande
dc.contributor.authorCinar, Ayca Kupeli
dc.contributor.authorCinar, Abdulkadir Can
dc.contributor.authorAkaray, Irfan
dc.contributor.authorAykutlu, Merve Sambel
dc.contributor.authorSakallioglu, Ahmet Kursad
dc.contributor.authorGurlu, Vuslat
dc.date.accessioned2024-06-12T11:02:40Z
dc.date.available2024-06-12T11:02:40Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim To investigate the corneal epithelial and limbal epithelial alterations in patients under topical glaucoma treatment using anterior segment-OCT (AS-OCT) and to determine the changes of the limbal region due to the preservatives and glaucoma drugs, that can progress to limbal stem cell deficiency (LSCD). Limbal thickness was measured by AS-OCT to evaluate limbal cell deficiency. Methods Forty-seven patients using topical medication for glaucoma, and 48 control subjects were enrolled in this matched case-control study. The patients were divided into four groups according to the treatment regimens. Group 1: One-drug regimen, Group 2: Two-drug regimen, Group 3: Three-drug regimen, Group 4: Four-drug regimen For the ocular surface evaluation; tear break-up time with standard fluorescein sodium sterile strip application, Schirmer test-I, Ocular Surface Disease Index Questionnaire, and AS-OCT were performed. Results A total of 95 subjects were included: 47 eyes of 47 patients with glaucoma medication and 48 eyes of 48 healthy subjects. There was a statistically significant difference between patients and controls according to BUT, SCH, and OSDI (p < 0.001). The mean central corneal epithelium thickness was 48.5 +/- 5.3 in patients and 54.5 +/- 5.9 in controls (p < 0.001). The mean central total corneal thickness was 529.2 +/- 41.2 in patients and 536 +/- 35.3 in controls (p = 0.335). The mean limbal epithelium thickness was 64.1 +/- 9.1 in patients and 76 +/- 11.5 in controls (p < 0.001). Conclusion Using at least one glaucoma drug caused limbal area injury, changed ocular surface measurements, and significantly reduced the limbal epithelial thickness where the stem cells reside. The limbal epithelial thickness measurement by AS-OCT seems to be an innovative, non-invasive, and promising technique for detecting and staging corneal damage in topical glaucoma therapy.en_US
dc.identifier.doi10.1080/15569527.2021.1902341
dc.identifier.endpage94en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue2en_US
dc.identifier.pmid33719786en_US
dc.identifier.scopus2-s2.0-85103242582en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2021.1902341
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21374
dc.identifier.volume40en_US
dc.identifier.wosWOS:000634132000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous And Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlaucoma Treatmenten_US
dc.subjectAnterior Segment OCTen_US
dc.subjectLimbal Stem Cell Deficiencyen_US
dc.subjectOSDIen_US
dc.subjectOcular Surface Diseaseen_US
dc.subjectStem-Cell Deficiencyen_US
dc.subjectBenzalkonium Chlorideen_US
dc.subjectThicknessen_US
dc.subjectDysfunctionen_US
dc.subjectDiagnosisen_US
dc.titleCorneal epithelium and limbal region alterations due to glaucoma medications evaluated by anterior segment optic coherence tomography: a case-control studyen_US
dc.typeArticleen_US

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