Rapid antidepressant effects of sleep deprivation therapy correlates with serum BDNF changes in major depression

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dc.authoridGorgulu, Yasemin/0000-0002-3401-4879
dc.authoridCaliyurt, Okan/0000-0002-0513-0619
dc.authorwosidCaliyurt, Okan/ABE-7339-2020
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.contributor.authorGorgulu, Yasemin
dc.contributor.authorCaliyurt, Okan
dc.date.accessioned2024-06-12T10:55:09Z
dc.date.available2024-06-12T10:55:09Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractRecent reports have suggested that brain-derived neurotrophic factor (BDNF) levels are reduced in individuals suffering major depressive disorder and these levels normalize following antidepressant treatment. Various antidepressants and electroconvulsive therapy are shown to have a positive effect on brain-derived neurotrophic factor levels in depressive patients. The aim of this study was to assess the effect of total sleep deprivation therapy on BDNF levels in major depressive patients. Patients were assigned to two treatment groups which consisted of 22 patients in the sertraline group and 19 patients in the total sleep deprivation plus sertraline group. Patients in the sleep deprivation group were treated with three total sleep deprivations in the first week of their treatment and received sertraline. Patients in sertraline group received only sertraline. BDNF levels were measured in the two treatment groups at baseline, 7th. 14th, and 42nd days. Patients were also evaluated using the Hamilton Rating Scale for Depression (HAM-D). A control group, consisting of 33 healthy volunteers had total sleep deprivation, BDNF levels and depression measured at baseline and after the total sleep deprivation. Results showed that serum BDNF levels were significantly lower at baseline in both treatment groups compared to controls. Decreased levels of BDNF were also negatively correlated with HAM-D scores. First single sleep deprivation and a series of three sleep deprivations accelerated the treatment response that significantly decreased HAM-D scores and increased BDNF levels. Total sleep deprivation and sertraline therapy is introduced to correlate with the rapid treatment response and BDNF changes in this study. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainresbull.2009.06.016
dc.identifier.endpage162en_US
dc.identifier.issn0361-9230
dc.identifier.issn1873-2747
dc.identifier.issue3en_US
dc.identifier.pmid19576267en_US
dc.identifier.scopus2-s2.0-68849089223en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainresbull.2009.06.016
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19301
dc.identifier.volume80en_US
dc.identifier.wosWOS:000270259300011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBrain Research Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain-Derived Neurotrophic Factoren_US
dc.subjectMajor Depressionen_US
dc.subjectSertralineen_US
dc.subjectTotal Sleep Deprivation Therapyen_US
dc.subjectNeurotrophic Factor Levelsen_US
dc.subjectProtein-Levelsen_US
dc.subjectRem-Sleepen_US
dc.subjectBrainen_US
dc.subjectNeuroplasticityen_US
dc.subjectExpressionen_US
dc.subjectMediationen_US
dc.subjectStressen_US
dc.titleRapid antidepressant effects of sleep deprivation therapy correlates with serum BDNF changes in major depressionen_US
dc.typeArticleen_US

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