The Impact of Everolimus and Radiation Therapy on Pulmonary Fibrosis

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dc.authoriday eren, ayfer/0000-0003-0641-3378
dc.authoridKilickap, Saadettin/0000-0003-1637-7390
dc.authoriday eren, ayfer/0000-0003-0641-3378
dc.authoridOZGUVEN, YILDIRAY/0000-0003-4060-2164
dc.authoridDaliparty, Vasudev Malik/0000-0002-8375-0514
dc.authorideren, mehmet fuat/0000-0002-6531-978X
dc.authorwosiday eren, ayfer/AAF-4095-2022
dc.authorwosidKilickap, Saadettin/AAP-3732-2021
dc.authorwosiday eren, ayfer/AFI-8458-2022
dc.authorwosideren, mehmet fuat/D-4816-2015
dc.contributor.authorEren, Mehmet Fuat
dc.contributor.authorEren, Ayfer Ay
dc.contributor.authorSayan, Mutlay
dc.contributor.authorYucel, Birsen
dc.contributor.authorElagoz, Sahende
dc.contributor.authorOzguven, Yildiray
dc.contributor.authorVergalasova, Irina
dc.date.accessioned2024-06-12T11:13:21Z
dc.date.available2024-06-12T11:13:21Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and objectives:Everolimus (EVE) is a mammalian target of the rapamycin (mTOR) inhibitor that is widely used in cancer patients. Pulmonary toxicity, usually manifesting as interstitial pneumonitis, is a serious adverse effect of this drug. Radiation therapy, which is often administered in conjunction with chemotherapy for synergistic effects, also causes pulmonary fibrosis. In view of pulmonary damage development in these two forms of cancer treatment, we have examined the effect of EVE administration individually, in combination with radiation given in varying sequences, and its relation to the extent of pulmonary damage.Materials and Methods:We performed an experimental study in albino rats, which were randomized into five groups: (1) control group, (2) EVE alone, (3) EVE 22 h after radiation, (4) EVE 2 h after irradiation, and (5) only radiation. Sixteen weeks after thoracic irradiation, rat lung tissue samples were examined under light microscopy, and the extent of pulmonary damage was estimated. After this, we calculated median fibrosis scores in each group.Results:The highest fibrosis score was noted in Group 4. Among the five groups, the control group had a significantly lower median fibrosis score compared to the others. When the median fibrosis score of the group that received concurrent EVE with radiation therapy (RT) (Group 4) was compared with that of the control group, the difference was statistically significant (p= 0.0022). However, no significant differences were achieved among the study groups that received EVE only or RT only, whether concurrently or sequentially (p> 0.05).Conclusion:EVE is an effective treatment option for the management of several malignancies and is often combined with other therapies, such as radiation, for a more efficient response. However, an increased risk of pulmonary fibrosis should also be anticipated when these two modalities are combined, as they both can cause pulmonary damage, especially when administered concurrently.en_US
dc.identifier.doi10.3390/medicina56070348
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue7en_US
dc.identifier.pmid32668776en_US
dc.identifier.scopus2-s2.0-85087835966en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/medicina56070348
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23507
dc.identifier.volume56en_US
dc.identifier.wosWOS:000557649500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMedicina-Lithuaniaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRadiation Therapyen_US
dc.subjectRaten_US
dc.subjectEverolimusen_US
dc.subjectPneumonitisen_US
dc.subjectPulmonary Fibrosisen_US
dc.subjectRenal-Cell Carcinomaen_US
dc.subjectMammalian Targeten_US
dc.subjectMtor Inhibitorsen_US
dc.subjectMechanismsen_US
dc.subjectToxicityen_US
dc.subjectCanceren_US
dc.titleThe Impact of Everolimus and Radiation Therapy on Pulmonary Fibrosisen_US
dc.typeArticleen_US

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