Investigation of the effects of naringin on intestinal ischemia reperfusion model at the ultrastructural and biochemical level

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dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042
dc.authoridUlucam, Enis/0000-0002-4686-7350
dc.authoridSanal, Filiz/0000-0002-5830-4811
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.authorwosidUlucam, Enis/AAG-9204-2019
dc.authorwosidBAKAR, Elvan/AAE-9247-2022
dc.authorwosidUluçam, Enis/HQZ-3831-2023
dc.authorwosidSanal, Filiz/O-9428-2019
dc.contributor.authorBakar, E.
dc.contributor.authorUlucam, E.
dc.contributor.authorCerkezkayabekir, A.
dc.contributor.authorSanal, F.
dc.contributor.authorInan, M.
dc.date.accessioned2024-06-12T11:07:06Z
dc.date.available2024-06-12T11:07:06Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe aimed to evaluate the ultrastructural effect of reversing cellular damage, occurring in rats due to ischemia-reperfusion (I/R) in the intestine, with naringin implementation through biochemical parameters. Rats were divided the sham/control, I/R and the naringin groups (n=7). For I/R group, 120 min of ischemia and 120 min of reperfusion was applied to the superior mesenteric artery. In the naringin group, after 120 min, 50 mg/kg naringin was implemented, and then 120 min of reperfusion was applied. Morphological evaluation was performed via Chiu score and electron microscopy. The antioxidant parameters were examined. Chiu score in I/R (p < 0.01) and naringin (p < 0.05) groups were higher than the sham/control group. In ultrastructural level some irregularity were observed in I/R group. Although it decreased in the naringin group, the damage was observed to continue. Malondialdehyde (MDA) amount and Superoxide dismutase activity (SOD) in I/R group were higher in comparison to the sham/control group (p < 0.01), while glutathione peroxidase activity (Gpx) was found to be lower (p < 0.01). SOD (p < 0.05) and MDA (p < 0.01) were decreased by naringin group. Gpx was decreased in I/R group compared to sham/control group (p < 0.01) and elevated due to naringin administration (p < 0.05). Catalase activity was observed to decrease in the naringin group compared to control and I/R groups (p < 0.01). It was determined that naringin provided limited healing at the ultrastructural level but also effected recovery within antioxidant parameters.en_US
dc.identifier.doi10.1016/j.biopha.2018.10.045
dc.identifier.endpage350en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid30399568en_US
dc.identifier.scopus2-s2.0-85055872514en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2018.10.045
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21896
dc.identifier.volume109en_US
dc.identifier.wosWOS:000452539100037en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectIntestineen_US
dc.subjectNaringinen_US
dc.subjectMalondialdehydeen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectRat Modelen_US
dc.subjectVitamin-Een_US
dc.subjectKidneyen_US
dc.subjectOzoneen_US
dc.subjectProanthocyanidinen_US
dc.subjectFormaldehydeen_US
dc.subjectDysfunctionen_US
dc.subjectInhibitionen_US
dc.titleInvestigation of the effects of naringin on intestinal ischemia reperfusion model at the ultrastructural and biochemical levelen_US
dc.typeArticleen_US

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