Efficacy of levobupivacaine wound infiltration with and without intravenous lornoxicam for post-varicocoele analgesia - A randomized, double-blind study

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dc.authoridAYDIN, GAYE KAYA/0000-0003-1441-9462
dc.authorwosidKaplan, Mustafa/D-4977-2014
dc.authorwosidAYDIN, GAYE KAYA/ABG-7300-2021
dc.contributor.authorMemis, Dilek
dc.contributor.authorHekimoglu, Sevtap
dc.contributor.authorKaya, Gaye
dc.contributor.authorAtakan, Huseyin I.
dc.contributor.authorKaplan, Mustafa
dc.date.accessioned2024-06-12T11:19:29Z
dc.date.available2024-06-12T11:19:29Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and objective: The oxicam NSAID lornoxicam is a potent analgesic with excellent anti-inflammatory properties in a range of painful and/or inflammatory conditions, including postoperative pain. Levobupivacaine, the S-(-)-isomer of bupivacaine, is a long-acting local anaesthetic that can be infiltrated into wounds for management of postoperative pain. We assessed the analgesic efficacy of lornoxicam when administered as an adjuvant to levobupivacaine wound infiltration after varicocoele operation. Methods: Sixty patients who underwent varicocoele surgery were randomly assigned to three different treatment groups. Before skin closure, patients received the following treatments: group I (n = 20) patients received normal saline 20 mL wound infiltration and intravenous lornoxicam (Xefo(R), Nycomed Pharma AS, Roskilde, Denmark) 2 mL (8 mg); group II (n = 20) patients received 0.25% levobupivacaine (Chirocaine(R), Abbott Scandinavia AB, Solna, Sweden) 10mL with normal saline 10 mL wound infiltration and intravenous normal saline 2 mL; group III (n = 20) patients received 0.25% levobupivacaine 10 mL with normal saline 10 mL wound infiltration and intravenous lornoxicam 2 mL (8 mg). Pain scores and total pethidine (meperidine) consumption were measured at 1, 2, 4, 6, 12 and 24 hours postoperatively. Time to first analgesic requirement and patient satisfaction were also compared post-surgery. Results: Pain scores during the first 6 hours postoperatively were significantly lower in group III than in group I and group II (p < 0.01). Total pethidine consumption was significantly lower in group HI (34.0 +/- 28.0 mg) than in group I (74.0 +/- 25 mg) and group II (76.0 +/- 29 mg) [p < 0.01]. Time to first analgesic was also significantly longer in group III (14.8 +/- 8.4 hours) than in group I (6.2 +/- 5.2 hours) and group II (5.8 +/- 7.1 hours) [p < 0.01]. The incidence of postoperative nausea and vomiting was significantly lower in group III than in group I and group II (p < 0.05). More patients in group III described their analgesia as good or excellent than in group I or group II (p < 0.01). Conclusion: In this study, levobupivacaine wound infiltration with adjuvant intravenous lornoxicam administration was associated with better postoperative analgesia during the early postoperative hours after varicocoele surgery than that induced by lornoxicam alone or levobupivacaine wound infiltration alone.en_US
dc.identifier.doi10.2165/00044011-200828060-00003
dc.identifier.endpage359en_US
dc.identifier.issn1173-2563
dc.identifier.issue6en_US
dc.identifier.pmid18479177en_US
dc.identifier.scopus2-s2.0-43649105613en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage353en_US
dc.identifier.urihttps://doi.org/10.2165/00044011-200828060-00003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25218
dc.identifier.volume28en_US
dc.identifier.wosWOS:000256735200003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAdis Int Ltden_US
dc.relation.ispartofClinical Drug Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNonsteroidal Antiinflammatory Drugsen_US
dc.subjectPostoperative Painen_US
dc.subjectBalanced Analgesiaen_US
dc.subjectBupivacaineen_US
dc.subjectSurgeryen_US
dc.subjectPharmacokineticsen_US
dc.subjectInstillationen_US
dc.subjectHysterectomyen_US
dc.subjectRopivacaineen_US
dc.subjectAnesthesiaen_US
dc.titleEfficacy of levobupivacaine wound infiltration with and without intravenous lornoxicam for post-varicocoele analgesia - A randomized, double-blind studyen_US
dc.typeArticleen_US

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