Intra-articular sodium hyaluronate injections after arthroscopic debridement for osteoarthritis of the knee: a prospective, randomized, controlled study

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dc.authorwosidheybeli, nurettin/ABA-8958-2020
dc.contributor.authorHeybeli, Nurettin
dc.contributor.authorDoral, Mahmut Nedim
dc.contributor.authorAtay, Ozgur Ahmet
dc.contributor.authorLeblebicioglu, Gursel
dc.contributor.authorUzumcugil, Akm
dc.date.accessioned2024-06-12T10:52:33Z
dc.date.available2024-06-12T10:52:33Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: The purpose of this study was to evaluate the effect of intra-articular hyaluronic acid (HA) injections after arthroscopic debridement on pain and functional parameters in patients with mild-to-moderate knee osteoarthritis. Methods: Sixty-seven patients (21 men, 46 women; mean age 56 years; range 40 to 65 years). who underwent standard arthroscopic debridement for primary knee osteoarthritis of Kellgren-Lawrence grade II-III were randomly assigned to HA injections (n=33) or to only follow-up as controls (n=34). Intra-articular sodium hyaluronate injections (Orthovisc) were started three weeks after arthroscopic debridement, totaling three injections interspersed with a week. The two groups were evaluated with the pain and physical function subscales of the WOMAC osteoarthritis index before and after 6, 12, and 24 weeks of arthroscopic debridement. Results: Improvement in pain scores at 6 weeks did not differ between the two groups (HA 21%, control 16%; p=0.478), whereas improvement in function scores was significantly higher in the HA group (23% vs 9.2%; p=0.018). The rates of improvement in pain and function scores increased in subsequent evaluations, but these did not differ significantly between the two groups. The percentages of patients who exhibited at least 30% and 40% improvement from baseline function scores were significantly greater in the HA group only at six weeks (p=0.025 and p=0.038, respectively). Conclusion: Intra-articular HA injections after arthroscopic debridement provide additional short-term benefits, but this combination therapy should be justified by further controlled studies with longer follow-up and larger patient groups.en_US
dc.identifier.doi10.3944/AOTT.2008.221
dc.identifier.endpage227en_US
dc.identifier.issn1017-995X
dc.identifier.issue4en_US
dc.identifier.pmid19060514en_US
dc.identifier.scopus2-s2.0-77952948093en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://doi.org/10.3944/AOTT.2008.221
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18756
dc.identifier.volume42en_US
dc.identifier.wosWOS:000262112900002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkish Assoc Orthopaedics Traumatologyen_US
dc.relation.ispartofActa Orthopaedica Et Traumatologica Turcicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArthroscopyen_US
dc.subjectCartilage, Articular/Surgeryen_US
dc.subjectDebridementen_US
dc.subjectHyaluronic Acid/Therapeutic Useen_US
dc.subjectInjections, Intra-Articularen_US
dc.subjectOsteoarthritis, Knee/Therapyen_US
dc.subjectArticular-Cartilageen_US
dc.subjectControlled-Trialen_US
dc.subjectTerm Efficacyen_US
dc.subjectAciden_US
dc.subjectLavageen_US
dc.subjectMetaanalysisen_US
dc.subjectManagementen_US
dc.subjectPlaceboen_US
dc.subjectCorticosteroidsen_US
dc.subjectModelen_US
dc.titleIntra-articular sodium hyaluronate injections after arthroscopic debridement for osteoarthritis of the knee: a prospective, randomized, controlled studyen_US
dc.typeArticleen_US

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