Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Basit Öğe Kaydı
dc.authoridÇapar, Gonca Duygu/0000-0002-5564-5776
dc.authoridÇapar, Gonca Duygu/0000-0002-5564-5776
dc.authoridYalcin, Gul Merve/0000-0002-7438-5834
dc.authoridOzcakir-Tomruk, Ceyda/0000-0003-1545-5588
dc.authorwosidEr, Nilay/HFI-7812-2022
dc.authorwosidÇapar, Gonca Duygu/AFN-7687-2022
dc.authorwosidÇapar, Gonca Duygu/ABA-1980-2020
dc.contributor.authorCapar, Gonca Duygu
dc.contributor.authorSapmaz-Metin, Melike
dc.contributor.authorKutan, Esma
dc.contributor.authorTomruk, Ceyda Ozcakir
dc.contributor.authorYalcin, Gul Merve
dc.contributor.authorEr, Nilay
dc.contributor.authorOzfidan, Gulnur Kizilay
dc.date.accessioned2024-06-12T10:55:19Z
dc.date.available2024-06-12T10:55:19Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the effect of doxycycline collagen sponge on bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the level of serum biomarkers as an indicator of osteonecrosis. Twenty-four rats were divided into four groups. Animals in the control group were injected with saline and animals in Groups I, II and III were injected with zoledronate three times a week for eight weeks. After eight weeks, the following procedures were performed in each group. In Group I: extraction of maxillary first molar, in Group II: extraction of maxillary first molar and mucoperiosteal coverage was performed and in Group III: extraction of maxillary first molar and mucoperiosteal coverage with doxycycline collagen sponges was performed. At the end of 16 weeks, all animals were sacrificed. Serum collagen type I C-telopeptide (CTx), tartrate-resistant acid phosphatase (TRACP 5b) and alkaline phosphatase (ALP) levels' analysis, clinical examination, histological and histomorphometrical analysis were performed. As a result no significant difference in CTx, TRACP 5b and ALP levels was observed between groups. Complete mucosal healing was observed in all animals in the control group and 66.7% of animals in Group III. The necrotic bone area in Group III was significantly lower than the other groups (p < 0.01). Statistically significant difference was observed between groups in terms of detached osteoclast number (p < 0.01). In conclusion, local application of doxycycline could have a positive effect in reducing the risk of BRONJ in rats.en_US
dc.identifier.doi10.1080/13102818.2016.1174078
dc.identifier.endpage761en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84978529150en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage752en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2016.1174078
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19381
dc.identifier.volume30en_US
dc.identifier.wosWOS:000381412200017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBRONJen_US
dc.subjectDoxycyclineen_US
dc.subjectCtxen_US
dc.subjectALPen_US
dc.subjectTRACP 5ben_US
dc.subjectCross-Linking Telopeptideen_US
dc.subjectSurgeons Position Paperen_US
dc.subjectAmerican Associationen_US
dc.subjectZoledronateen_US
dc.subjectOsteoclastsen_US
dc.subjectMechanismsen_US
dc.subjectMarkersen_US
dc.subjectProfileen_US
dc.subjectRisken_US
dc.subjectRatsen_US
dc.titlePreventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu