Evaluation of circulating miRNAs in wet age-related macular degeneration

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dc.authoridBALCI, Senay/0000-0002-7498-604X
dc.authoridAYAZ, LOKMAN/0000-0002-2876-055X
dc.authorwosidTamer, Lulufer/AAG-5796-2021
dc.authorwosidBALCI, Senay/W-4931-2019
dc.authorwosidAYAZ, LOKMAN/K-6716-2013
dc.contributor.authorErtekin, Sevda
dc.contributor.authorYildirim, Ozlem
dc.contributor.authorDinc, Erdem
dc.contributor.authorAyaz, Lokman
dc.contributor.authorFidanci, Senay Balci
dc.contributor.authorTamer, Lulufer
dc.date.accessioned2024-06-12T11:19:35Z
dc.date.available2024-06-12T11:19:35Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: In the present study, we aimed to investigate the changes in plasma miRNA in patients with wet age-related macular degeneration. Methods: The expression profiles of 384 miRNAs in plasma from 33 patients (22 male, 11 female) who were diagnosed with wet age-related macular degeneration with fundus examination, fundus fluorescein angiography, and optical coherence tomography and 31 controls (17 male, 14 female) were evaluated using high-throughput quantitative real-time PCR. Results: Our results demonstrated that the expression level of five miRNAs (miR-17-5p, miR-20a-5p, miR-24-3p, miR-106a-5p, and miR-223-3p) was significantly upregulated in patients with age-related macular degeneration when compared to the control group (p<0.05). The expression level of 11 miRNAs (miR-21-5p, miR-25-3p, miR-140-3p, miR-146b-5p, miR-192-5p, miR-335-5p, miR-342-3p, miR-374a-5p, miR-410, miR-574-3p, and miR-660-5p) was significantly downregulated in patients (p<0.05). In addition, ten miRNAs (miR-26b-5p, miR-27b-3p, miR-29a-3p, miR-139-3p, miR-212-3p, miR-324-3p, miR-324-5p, miR-532-3p, miR-744-5p, and miR-Let-7c) were expressed only in the patient group. Conclusions: Our results suggest that plasma miRNA levels may change in wet age-related macular degeneration. These molecules may have an important therapeutic target in patients who are unresponsive to antivascular endothelial growth factor therapy. However, further studies must be conducted for possible effects of miRNAs in vascular disorders of eye such as age-related macular degeneration.en_US
dc.description.sponsorshipMersin University Scientific Research Fund [BAP-TF CTB (SE) 201- TU]en_US
dc.description.sponsorshipThe authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. This study was supported by Mersin University Scientific Research Fund (Grant No: BAP-TF CTB (SE) 201- TU). The authors thank Aysegul Gorur for helping miRNA analysis.en_US
dc.identifier.endpage1066en_US
dc.identifier.issn1090-0535
dc.identifier.pmid25221421en_US
dc.identifier.scopus2-s2.0-84905271740en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1057en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25268
dc.identifier.volume20en_US
dc.identifier.wosWOS:000341972500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMolecular Visionen_US
dc.relation.ispartofMolecular Visionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPigment Epithelial-Cellsen_US
dc.subjectChoroidal Neovascularizationen_US
dc.subjectDifferential Expressionen_US
dc.subjectMicrorna Expressionen_US
dc.subjectBreast-Canceren_US
dc.subjectGrowth-Factoren_US
dc.subjectAngiogenesisen_US
dc.subjectInvasionen_US
dc.subjectTargetsen_US
dc.subjectPlasmaen_US
dc.titleEvaluation of circulating miRNAs in wet age-related macular degenerationen_US
dc.typeArticleen_US

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