Hemophagocytic syndrome in one patient with adult-onset Still's disease

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dc.authorwosidCakir, Necati/AAG-7283-2019
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorPamuk, Gulsum Emel
dc.contributor.authorUsta, Ufuk
dc.contributor.authorCakir, Necati
dc.date.accessioned2024-06-12T10:50:52Z
dc.date.available2024-06-12T10:50:52Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMacrophage activation syndrome (MAS) is an important complication seen in systemic for juvenile rheumatoid arthritis; until now, it has been reported in only a few cases of adult-onset Still's disease (AOSD). Here, we shall present a 50-year-old female patient who was using steroids and antimalarial drugs for AOSD, and who developed MAS during follow-up. The patient presented with febrile neutropenia, and the neutropenic period lasted for 15 days. The examination of bone marrow aspiration smears demonstrated increased macrophages and findings of hemophagocytosis. Flow cytometric analysis of peripheral blood showed decreased natural killer cells. The patient developed neurologic findings during this period, and during the recovery of neutropenia, she had icterus and liver function test abnormalities. The patient was given granulocyte colony-stimulating factor during neutropenic period, and her neutropenia improved after the administration of high-dose steroids. Our patient was the first AOSD patient who presented with febrile neutropenia during the course of her disease and who was diagnosed to have MAS.en_US
dc.identifier.doi10.1007/s10067-006-0238-x
dc.identifier.endpage800en_US
dc.identifier.issn0770-3198
dc.identifier.issue5en_US
dc.identifier.pmid16550302en_US
dc.identifier.scopus2-s2.0-34147099666en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage797en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-006-0238-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18159
dc.identifier.volume26en_US
dc.identifier.wosWOS:000245428100031en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdult-Onset Still's Diseaseen_US
dc.subjectFebrile Neutropeniaen_US
dc.subjectHemophagocytosisen_US
dc.subjectMacrophage Activation Syndromeen_US
dc.subjectMacrophage Activation Syndromeen_US
dc.subjectJuvenile Rheumatoid-Arthritisen_US
dc.subjectLymphohistiocytosisen_US
dc.subjectCyclosporineen_US
dc.subjectNeutropeniaen_US
dc.subjectDysfunctionen_US
dc.titleHemophagocytic syndrome in one patient with adult-onset Still's diseaseen_US
dc.typeArticleen_US

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