Outcomes of Fecal Carriage of Extended-spectrum ?-Lactamase After Transrectal Ultrasound-guided Biopsy of the Prostate

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dc.authoridTukenmez Tigen, Elif/0000-0003-2027-4116
dc.authoridgelmez, gulsen altınkanat/0000-0003-0274-628X
dc.authoridErgonul, Onder/0000-0003-1935-9235
dc.authoridERTURK SENGEL, BUKET/0000-0003-2182-4693
dc.authoridKorten, VolkanO/0000-0002-9991-814X;
dc.authorwosidTukenmez Tigen, Elif/AAN-5897-2021
dc.authorwosidTürkeri, Levent N./W-9283-2018
dc.authorwosidgelmez, gulsen altınkanat/Q-2516-2015
dc.authorwosidErgonul, Onder/GPK-0581-2022
dc.authorwosidERTURK SENGEL, BUKET/HKN-8502-2023
dc.authorwosidKorten, VolkanO/HGT-7791-2022
dc.authorwosidGünaydın, Bilal/HMO-9127-2023
dc.contributor.authorTigen, Elif Tukenmez
dc.contributor.authorTandogdu, Zafer
dc.contributor.authorErgonul, Onder
dc.contributor.authorAltinkanat, Gulsen
dc.contributor.authorGunaydin, Bilal
dc.contributor.authorOzgen, Mahir
dc.contributor.authorSariguzel, Nevin
dc.date.accessioned2024-06-12T11:18:50Z
dc.date.available2024-06-12T11:18:50Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE To determine the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (PE) fecal carriage in patients that undergo transrectal ultrasonography-guided biopsy (TRUSbx) and its relationship with post-biopsy infections. METHODS A prospective clinical study in 4 different tertiary hospitals between 2008 and 2010 was conducted. Four hundred men with sterile urine who were to undergo a TRUSbx because of the suspicion of prostate cancer were included and followed for 14 days after biopsy. Rectal swab culture specimens were acquired immediately before the procedure. Demographic data, prophylaxis choice, quinolone or any other antibiotic consumption within the past 2 months, history of prostatitis, repeat biopsy, intensive care unit admission, hospitalization, urethral catheterization, diabetes mellitus (DM), and steroid usage were recorded. RESULTS ESBL carriage was detected in 19% of patients and quinolone use within the last 2 months; other antibiotic use within the last 2 months and DM were found to be significantly associated (P < .05). Symptomatic urinary tract infection (UTI) on the third day after biopsy was seen in 9% of patients and was associated with fluoroquinolone (FQ) consumption before biopsy. Although ESBL-PE carriage was associated with post-biopsy UTI symptoms, it was not found to be associated with post-biopsy symptomatic UTI. Urosepsis was seen in 2 patients (0.5%) after biopsy, and both the patients were ESBL-PE carriers. CONCLUSION The presence of ESBL-PE was associated with DM and FQ consumption before biopsy. ESBL-PE carriage was associated with a high rate of post-biopsy UTI symptoms requiring further elucidation; however, it was not associated with microbiologically proven infections. FQ consumption before TRUSbx was also associated with post-biopsy infections. (C) 2014 Elsevier Inc.en_US
dc.description.sponsorshipMerc Sharp; Dohme Corporationen_US
dc.description.sponsorshipThe study was funded by Merc Sharp and Dohme Corporation.en_US
dc.identifier.doi10.1016/j.urology.2014.04.060
dc.identifier.endpage1014en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84908336521en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1008en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2014.04.060
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24983
dc.identifier.volume84en_US
dc.identifier.wosWOS:000344478700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEscherichia-Colien_US
dc.subjectAntibiotic-Prophylaxisen_US
dc.subjectRisk-Factorsen_US
dc.subjectInfectious Complicationsen_US
dc.subjectCore Biopsiesen_US
dc.subjectPrevalenceen_US
dc.subjectEnterobacteriaceaeen_US
dc.subjectColonizationen_US
dc.subjectCommunityen_US
dc.subjectImpacten_US
dc.titleOutcomes of Fecal Carriage of Extended-spectrum ?-Lactamase After Transrectal Ultrasound-guided Biopsy of the Prostateen_US
dc.typeArticleen_US

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