The protective effects of melatonin and vitamin E against renal ischemia-reperfusion injury in rats

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881;
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorAktoz, Tevfik
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorAlagol, Bulent
dc.contributor.authorYalcin, Omer
dc.contributor.authorHuseyinova, Gulara
dc.contributor.authorAtakan, Irfan Huseyin
dc.date.accessioned2024-06-12T11:07:17Z
dc.date.available2024-06-12T11:07:17Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractReactive oxygen species (ROS) were shown to contribute to the cellular damage induced by ischemia-reperfusion. The purpose of this study was to investigate and compare the efficiency of melatonin and vitamin E in the reduction of injury induced by ROS in a rat model of renal ischemia-reperfusion. Twenty-four Wistar-albino rats were divided into four groups. Rats in the Sham group were given saline 1 mL/kg, intraperitoneally (ip) 72 h, 48 h, 24 h, and 30 min before the sham operation. Rats in ischemia-reperfusion (IR), IR+Melatonin, and IR+Vitamin E groups were given saline (1 mL/ kg), melatonin (10 mg/kg), and vitamin E (100 mg/kg) ip, respectively, 72 h, 48 h, 24 h, and 30 min before the ischemia for 60 min, followed by reperfusion for 60 min. The blood samples and kidney tissues of the rats were taken under anesthesia. lschemia-reperfusion significantly increased urea, creatinine, and malondialdehyde (MDA) levels, and decreased superoxide dismutase (SOD) and catalase (CAT) activities. Histopathological findings of the IR group confirmed that there was renal impairment by cast formation and tubular necrosis in the tubular epithelium. In the IR+Melatonin group, while MDA levels significantly decreased, SOD activities increased. In the IR+Melatonin group, the level of tubular necrosis and cast formation are significantly decreased than those seen in the ischemia-reperfusion group. Melatonin in particular was effective to reverse hot ischemia of kidney by its antioxidant effects. These results may indicate that melatonin pretreatment protects against functional, biochemical, and morphological damage better than vitamin E in renal ischemia-reperfusion injury.en_US
dc.identifier.doi10.1080/08860220701391738
dc.identifier.endpage542en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue5en_US
dc.identifier.pmid17654314en_US
dc.identifier.scopus2-s2.0-34547185043en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage535en_US
dc.identifier.urihttps://doi.org/10.1080/08860220701391738
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21981
dc.identifier.volume29en_US
dc.identifier.wosWOS:000248539800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectMelatoninen_US
dc.subjectVitamin Een_US
dc.subjectAntioxidanten_US
dc.subjectKidneyen_US
dc.subjectAcid Phenethyl Esteren_US
dc.subjectAlpha-Tocopherolen_US
dc.subjectNitric-Oxideen_US
dc.subjectDamageen_US
dc.subjectAntioxidanten_US
dc.subjectToxicityen_US
dc.subjectPreventsen_US
dc.subjectAssayen_US
dc.titleThe protective effects of melatonin and vitamin E against renal ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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