Capecitabine-related intracranial hypotension syndrome mimicking dural metastasis in a breast cancer patient: Case report and review of the literature

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dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridDepboylu Denizli, Bengu/0000-0002-9777-2917
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.authorwosidDepboylu Denizli, Bengu/B-9156-2019
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.contributor.authorCosar-Alas, Rusen
dc.contributor.authorAlas, Aykan
dc.contributor.authorOzen, Alaattin
dc.contributor.authorDenizli, Bengu
dc.contributor.authorSaynak, Mert
dc.contributor.authorUzunoglu, Sernaz
dc.contributor.authorAydogdu, Nurettin
dc.date.accessioned2024-06-12T10:55:41Z
dc.date.available2024-06-12T10:55:41Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSpontaneous intracranial hypotension (SICH) is an entity, which is secondary to iatrogenic manipulation and breaching of dura. Postural headache in patients should be suspected, cranial magnetic resonance imaging (MRI) is essential for precise diagnosis. Hallmark of MRI is regular shape of pachymeningeal gadolinium enhancement and subdural effusion. It may mimic central nervous system (CNS) metastasis. Prevention of such cases from receiving cranial radiotherapy by misinterpretation of the gadolinium enhancement as CNS metastasis is an important issue. Capecitabine is an antineoplastic agent, of which metabolites can cross blood-brain barrier in CNS via epithelial tissue. It may cause decrease in CSF production. SICH might be the clinical reflection of this decrease in CSF production. Review of the English literature revealed limited data because of the very little experience with oncologic patients suffering from intracranial hypotension. We report a case of spontaneous intracranial hypotension during capecitabine treatment. Patient was completely well following drug discontinuation and supportive treatment.en_US
dc.identifier.doi10.4103/0973-1482.77070
dc.identifier.endpage559en_US
dc.identifier.issn0973-1482
dc.identifier.issue4en_US
dc.identifier.pmid21358101en_US
dc.identifier.scopus2-s2.0-79952395802en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage557en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1482.77070
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19495
dc.identifier.volume6en_US
dc.identifier.wosWOS:000288028700030en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publicationsen_US
dc.relation.ispartofJournal Of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCapecitabineen_US
dc.subjectMimicking Dural Metastasisen_US
dc.subjectOrthostatic Headacheen_US
dc.subjectSpontaneous Intracranial Hypotension Syndromeen_US
dc.subjectCerebrospinal-Fluiden_US
dc.subjectMrien_US
dc.titleCapecitabine-related intracranial hypotension syndrome mimicking dural metastasis in a breast cancer patient: Case report and review of the literatureen_US
dc.typeReview Articleen_US

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