The Role of Vaginal pH on Efficacy of Controlled-Release Dinoprostone Vaginal Insert for Cervical Ripening/Labor Induction: A Prospective Double-Blind Study

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dc.authoridGungor, Tayfun/0000-0002-7869-9662
dc.authorwosidYilmaz, Bulent/GPK-8613-2022
dc.authorwosidYilmaz, Bulent/HKE-5048-2023
dc.contributor.authorOnen, Fiahin
dc.contributor.authorOzaksit, Gulnur
dc.contributor.authorYilmaz, Bulent
dc.contributor.authorGungor, Tayfun
dc.contributor.authorBilge, Umit
dc.contributor.authorSut, Necdet
dc.contributor.authorMollamahmutoglu, Leyla
dc.date.accessioned2024-06-12T10:59:38Z
dc.date.available2024-06-12T10:59:38Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To evaluate if vaginal pH has any effect on the efficacy of controlled-release PGE 2 vaginal insert for cervical ripening/labor induction in post-term patients. Materials and Methods: Sixty-three post-term women with unfavorable cervix (Bishop's score +/- 6) undergoing labor induction were enrolled in this prospective, double-blinded trial. All patients received sustained-release dinoprostone vaginal insert for cervical ripening/labor induction during 12 hours, repeated dosing one time 24 hours later. Results: Women with a low vaginal pH (>4.5, n= 38) and women with a high vaginal pH (> 4.5, n= 25) were similar in maternal age, parity, body mass index, gestational age or initial Bishop's score. Bishop's score change over the initial 12 hours significantly (p<0.05) differed between the low vaginal pH (3.9 +/- 3.3) and the high vaginal pH group (5.5 +/- 3.4). Time to active labor (14.7 +/- 17.3 hrs vs 13.1 +/- 9.8 hrs), complete dilation (19.6 +/- 20.1 hrs vs 17.1 +/- 11.8 hrs) and delivery (20.0 +/- 21.4 hrs vs 17.6 +/- 12.0 hrs) were comparable between the low and high vaginal pH groups, respectively. Linear regression analysis revealed no significant association between vaginal pH and Bishop's score change over 12 hours, time to active labor, time to complete dilation, or time to delivery. Discussion: Vaginal pH has significant effect on cervical ripening but has no effect on delivery outcomes in post-term patients with unfavorable cervices, who undergo cervical priming/labor induction using sustained-release dinoprostone vaginal insert.en_US
dc.identifier.endpage211en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue4en_US
dc.identifier.startpage206en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20508
dc.identifier.volume9en_US
dc.identifier.wosWOS:000420607600005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal Of The Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDinoprostone Vaginal Inserten_US
dc.subjectVaginal Phen_US
dc.subjectCervical Ripeningen_US
dc.subjectLabor Inductionen_US
dc.subjectRandomized-Trialen_US
dc.subjectProstaglandin E-2en_US
dc.subjectEndocervical Preparationsen_US
dc.subjectLabor Inductionen_US
dc.subjectClinical-Trialen_US
dc.subjectGelen_US
dc.subjectMisoprostolen_US
dc.subjectPessaryen_US
dc.subjectPge(2)en_US
dc.subjectSalineen_US
dc.titleThe Role of Vaginal pH on Efficacy of Controlled-Release Dinoprostone Vaginal Insert for Cervical Ripening/Labor Induction: A Prospective Double-Blind Studyen_US
dc.typeArticleen_US

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