Using urine FTIR spectra to screen autism spectrum disorder

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dc.authoridBOZATLI, Leyla/0000-0002-4701-4835
dc.authoridSARIGUL, NESLIHAN/0000-0002-5371-7924
dc.authoridKorkmaz, Filiz/0000-0003-3512-3521
dc.authorwosidBOZATLI, Leyla/B-1442-2019
dc.authorwosidSARIGUL, NESLIHAN/J-1564-2013
dc.authorwosidKorkmaz, Filiz/GOH-1457-2022
dc.contributor.authorSarigul, Neslihan
dc.contributor.authorBozatli, Leyla
dc.contributor.authorKurultak, Ilhan
dc.contributor.authorKorkmaz, Filiz
dc.date.accessioned2024-06-12T11:19:31Z
dc.date.available2024-06-12T11:19:31Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAutism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder caused by multiple factors, lacking clear biomarkers. Diagnosing ASD still relies on behavioural and developmental signs and usually requires lengthy observation periods, all of which are demanding for both clinicians and parents. Although many studies have revealed valuable knowledge in this field, no clearly defined, practical, and widely acceptable diagnostic tool exists. In this study, 26 children with ASD (ASD+), aged 3-5 years, and 26 sex and age-matched controls are studied to investigate the diagnostic potential of the Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy. The urine FTIR spectrum results show a downward trend in the 3000-2600/cm region for ASD+ children when compared to the typically developing (TD) children of the same age. The average area of this region is 25% less in ASD+ level 3 children, 29% less in ASD+ level 2 children, and 16% less in ASD+ level 1 children compared to that of the TD children. Principal component analysis was applied to the two groups using the entire spectrum window and five peaks were identified for further analysis. The correlation between the peaks and natural urine components is validated by artificial urine solutions. Less-than-normal levels of uric acid, phosphate groups, and ammonium (NH4+) can be listed as probable causes. This study shows that ATR-FTIR can serve as a practical and non-invasive method to screen ASD using the high-frequency region of the urine spectrum.en_US
dc.identifier.doi10.1038/s41598-023-46507-z
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid37945643en_US
dc.identifier.scopus2-s2.0-85176122146en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-023-46507-z
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25238
dc.identifier.volume13en_US
dc.identifier.wosWOS:001106459000064en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectChildrenen_US
dc.subjectBiomarkersen_US
dc.subjectMetabolomicsen_US
dc.subjectAmmoniaen_US
dc.subjectAcidsen_US
dc.subjectUreaen_US
dc.titleUsing urine FTIR spectra to screen autism spectrum disorderen_US
dc.typeArticleen_US

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