The role of postoperative radiotherapy in node negative breast cancer patients with pT3-T4 disease

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dc.authoridFayda, Merdan/0000-0002-2800-5327;
dc.authorwosidFayda, Merdan/F-5092-2012
dc.authorwosidSaip, pınar/AAT-1500-2020
dc.authorwosidFayda, Merdan/AAF-7370-2019
dc.authorwosidküçücük, seden/JWP-5854-2024
dc.authorwosidBaskaya, Senol/AAM-7155-2020
dc.contributor.authorAksu, G.
dc.contributor.authorKucucuk, S.
dc.contributor.authorFayda, M.
dc.contributor.authorSaynak, M.
dc.contributor.authorBaskaya, S.
dc.contributor.authorSaip, P.
dc.contributor.authorOzturk, N.
dc.date.accessioned2024-06-12T10:55:15Z
dc.date.available2024-06-12T10:55:15Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAims: To evaluate the role of postmastectomy radiotherapy (PMRT) in patients with pT3-T4N0M0 breast cancer. Methods: 156 patients with T3-T4N0M0 breast cancer were retrospectively analyzed. Results: Locoregional recurrences were seen in 17 of 156 patients with a median time for development of 27 months (5.7-248.7 months). Two of 9 patients who were not treated with post-operative radiation therapy had locoregional recurrence as compared with 16 of 147 patients receiving radiotherapy. In multivariate analysis, presence of locoregional recurrence was the only significant prognostic factor for overall survival (18% vs. 86%, p < 0.001, RR = 9.05). The patients with a median number of dissected lymph nodes >= 10 had a significantly better locoregional disease free survival rate as compared with patients with dissected lymph nodes < 10 (90% vs. 78%, p = 0.04). Chest wall recurrences were clearly higher in patients without chest wall RT since 5 of 49 patients without RT had recurrences in the chest wall region while only 4 of 107 who received chest wall RT had recurrence. However receiving RT to peripherical lymphatic regions had no additional effect on reducing recurrences in these regions (5% vs. 4%). Conclusions: Due to the lack of phase III randomized trials directly addressing the role of postmastectomy radiotherapy in these stages, our series suggest that postmastectomy radiotherapy to the ipsilateral chest wall is recommended for patients with PT3N0 and T4N0 breast cancer. The need for irradiating axillary or supraclavicular region shall be neglected in patients who undergo sufficient axillary sampling. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejso.2006.10.037
dc.identifier.endpage293en_US
dc.identifier.issn0748-7983
dc.identifier.issue3en_US
dc.identifier.pmid17145158en_US
dc.identifier.scopus2-s2.0-33947680781en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage285en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejso.2006.10.037
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19355
dc.identifier.volume33en_US
dc.identifier.wosWOS:000246067100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofEjsoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectT3N0en_US
dc.subjectNode-Negative Diseaseen_US
dc.subjectRadiotherapyen_US
dc.subjectPrognostic Factorsen_US
dc.subjectLocoregional Recurrenceen_US
dc.subjectTerm-Follow-Upen_US
dc.subjectLocoregional Recurrenceen_US
dc.subjectPrognostic-Factorsen_US
dc.subjectPremenopausal Womenen_US
dc.subjectNatural-Historyen_US
dc.subjectChemotherapyen_US
dc.subjectCarcinomaen_US
dc.subjectStageen_US
dc.subjectMastectomyen_US
dc.subjectSurvivalen_US
dc.titleThe role of postoperative radiotherapy in node negative breast cancer patients with pT3-T4 diseaseen_US
dc.typeArticleen_US

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