Effects of Intraperitoneal Melatonin on Caustic Sclerosing Cholangitis Due to Scolicidal Solution in a Rat Model

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.contributor.authorSezer, Atakan
dc.contributor.authorHatipoglu, Ahmet Rahmi
dc.contributor.authorUsta, Ufuk
dc.contributor.authorAltun, Guelay
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:08:14Z
dc.date.available2024-06-12T11:08:14Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND: Hydatid disease is a worldwide health problem. Treatment is surgical or percutaneous, using scolicidal agents. Caustic sclerosing cholangitis might develop after the contact of scolicidal agents with the biliary ducts. Melatonin, an antioxidant, anti-inflammatory, and anticarcinogenic agent, might be used in the treatment of caustic sclerosing cholangitis due to its possible preventive effects on fibrosis and cell damage. OBJECTIVE: The aim of the study was to investigate the effects of melatonin on an experimentally developed caustic sclerosing cholangitis with scolicidal solution (formalin) in a rat model. METHODS: Forty female Sprague-Dawley rats aged 11 to 13 weeks and weighing 250 +/- 30 g were randomly assigned to 1 of 4 groups of 10: formalin 5% at 0.5 mL/d + melatonin placebo; formalin placebo + intraperitoneal melatonin 10 mg/kg/d; formalin 5% at 0.5 mL/d + melatonin 10 mg/kg/d; and formalin placebo and melatonin placebo (control). Hepatobiliary function was assessed using dynamic scintigraphy with technetium-99m-mebrofenin on study day 60. The histology of the liver and biliary duct specimens was examined on study day 60. In each group, histopathologic alterations were scored as absent, slight, mild, or severe. RESULTS: Mean severity scores for parenchymal necrosis in the liver (P < 0.01), portal fibrosis (P < 0.01), biliary duct proliferation (P < 0.001), cholangitis/pericholangitis (P < 0.01), hyperemia in the biliary ducts (P < 0.01), and fibrosis (P < 0.01) were significantly lower in rats treated with formalin + melatonin compared with those treated with formalin alone. No significant differences were observed between the 3 treatment groups with respect to t(1/2), a parameter used to assess the secretion function of the hepatocytes. However, the t(1/2) was significantly longer in the treatment groups compared with controls (P < 0.001). CONCLUSION: In this experimental study in a rat model of caustic sclerosing cholangitis, the histopathologic and scintigraphic findings suggested that melatonin is effective in attenuating the damage caused by scolicidal agents on the liver and biliary ducts. (Curr Ther Res Clin Exp. 2010;71:118-128) (C) 2010 Excerpta Medica Inc.en_US
dc.identifier.doi10.1016/j.curtheres.2010.03.004
dc.identifier.endpage128en_US
dc.identifier.issn0011-393X
dc.identifier.issue2en_US
dc.identifier.pmid24683258en_US
dc.identifier.scopus2-s2.0-77951972990en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage118en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2010.03.004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22361
dc.identifier.volume71en_US
dc.identifier.wosWOS:000277226400005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical And Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMelatoninen_US
dc.subjectHydatid Cysten_US
dc.subjectScolicidal Solutionsen_US
dc.subjectCaustic Sclerosing Cholangitisen_US
dc.subjectOxidative Stressen_US
dc.subjectSurgical-Treatmenten_US
dc.subjectHydatid-Diseaseen_US
dc.subjectBiliary Treeen_US
dc.subjectLiveren_US
dc.subjectCystsen_US
dc.subjectThioacetamideen_US
dc.subjectFormaldehydeen_US
dc.titleEffects of Intraperitoneal Melatonin on Caustic Sclerosing Cholangitis Due to Scolicidal Solution in a Rat Modelen_US
dc.typeArticleen_US

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