Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats

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dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridOltulu, Cagatay/0000-0002-6051-3479
dc.authorwosidgüven, Rabia/HCI-4600-2022
dc.authorwosidgüven, Rabia/B-2261-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidOltulu, Cagatay/V-1823-2018
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorOltulu, Cagatay
dc.contributor.authorGuven, Rabia
dc.contributor.authorBuldum, Dilek
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T11:09:10Z
dc.date.available2024-06-12T11:09:10Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of the present study was to develop a new experimental pain model by adapting the chronic constriction injury (CCI) model of the sciatic nerve to the exclusively sensory saphenous nerve in rats. Animals were divided into na < ve, sham, and two experimental groups, in which two or four 4-0 chromic gut ligatures were loosely ligated around the saphenous nerve. Then, behavioral signs of neuropathic pain were observed for 8 weeks. In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures. Pharmacological analysis was made in rats with four loose ligations; morphine and WIN 55,212-2, a cannabinoid agonist, reversed all of the modalities tested, whereas gabapentin only suppressed mechanical allodynia and amitriptyline only reduced mechanical hyperalgesia. Our data establish a rat model of saphenous CCI with significant allodynia and hyperalgesia, which is sensitive to a number of analgesic compounds.en_US
dc.identifier.doi10.1007/s10072-011-0761-7
dc.identifier.endpage1142en_US
dc.identifier.issn1590-1874
dc.identifier.issue6en_US
dc.identifier.pmid21909745en_US
dc.identifier.scopus2-s2.0-84856216175en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1135en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-011-0761-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22696
dc.identifier.volume32en_US
dc.identifier.wosWOS:000297546800019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuropathic Painen_US
dc.subjectAllodyniaen_US
dc.subjectHyperalgesiaen_US
dc.subjectAnimal Modelen_US
dc.subjectSaphenous Nerveen_US
dc.subjectSpared Nerve Injuryen_US
dc.subjectPeripheral Mononeuropathyen_US
dc.subjectMechanical Allodyniaen_US
dc.subjectCannabinoid Agonisten_US
dc.subjectDynamic Componentsen_US
dc.subjectTactile Allodyniaen_US
dc.subjectDiabetic-Ratsen_US
dc.subjectAmitriptylineen_US
dc.subjectHyperalgesiaen_US
dc.subjectLigationen_US
dc.titlePharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in ratsen_US
dc.typeArticleen_US

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