Immunosupressive Phenolic Constituents from Hypericum montbretii Spach.

Basit Öğe Kaydı
dc.authoridMesaik, M. Ahmed/0000-0003-2010-2568
dc.authoridChoudhary, M. Iqbal/0000-0001-5356-3585
dc.authorwosidMesaik, M. Ahmed/GRE-9332-2022
dc.authorwosidchaudhary, Muhammad iqbal/E-8638-2015
dc.authorwosidChoudhary, M. Iqbal/C-8633-2012
dc.contributor.authorDemirkiran, Ozlem
dc.contributor.authorMesaik, M. Ahmad
dc.contributor.authorBeynek, Hayrettin
dc.contributor.authorAbbaskhan, Ahmed
dc.contributor.authorChoudhary, M. Iqbal
dc.date.accessioned2024-06-12T11:03:35Z
dc.date.available2024-06-12T11:03:35Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe MeOH extract of aerial parts of H. monbretii Spach. have yielded quercetin (1), kaempferol (2), quercitrin (3), hyperin (4), myricitrin (5), rutin (6), I 3 II 8 '' biapigenin (7), methyl chlorogenate (8), 5-O-p-coumaroylquinic acid (9), and chlorogenic acid (5-O-caffeoyl quinic acid) (10), mangiferin (11), and shikimic acid (12). Three compounds 1, 2 and 4 were found to have an immunomodulating inhibitory activity on the oxidative burst response of human neutrophils, as well on mouse peritoneal macrophages. Effects of compounds on whole blood phagocytes activity was found to be with IC50 ranging between 8.0-12.2 mu g/mL. Only compounds 1, and 2 were found to interfere with T-cell proliferation, and IL-2 release in PHA activated peripheral blood mononuclear cells system. To the best of our knowledge, this is the first report of phytochemical and biological activity study on H. montbretii Spach.en_US
dc.description.sponsorshipHigher Education Commission of Pakistan [20-684 RD 2007]; Trakya University Research Projects Commision [TUBAP-387]; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (Pakistan)en_US
dc.description.sponsorshipThis work was supported by a grant 20-684 R&D 2007 of Higher Education Commission of Pakistan, and grant TUBAP-387 of Trakya University Research Projects Commision. One of the authors (Ozlem Demirkiran) is grateful to the H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (Pakistan) for the financial support.en_US
dc.identifier.endpage219en_US
dc.identifier.issn1307-6167
dc.identifier.issue3en_US
dc.identifier.startpage210en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21693
dc.identifier.volume7en_US
dc.identifier.wosWOS:000319558500007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAcg Publicationsen_US
dc.relation.ispartofRecords Of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypericum Monbretii Spach.en_US
dc.subjectPhenolicsen_US
dc.subjectImmunomodulating Inhibitory Activityen_US
dc.subjectReactive Oxygen Speciesen_US
dc.subjectT-Cell Proliferationen_US
dc.subjectIL-2 Productionen_US
dc.subjectSt-Johns-Worten_US
dc.subjectAlzheimers-Diseaseen_US
dc.subjectChemi-Luminescenceen_US
dc.subjectOxidative Stressen_US
dc.subjectCell-Culturesen_US
dc.subjectT-Cellsen_US
dc.subjectAntioxidantsen_US
dc.subjectXanthonesen_US
dc.titleImmunosupressive Phenolic Constituents from Hypericum montbretii Spach.en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu