Relationship between second-trimester amniotic fluid and plasma levels of angiopoietin-2 and thrombomodulin with adverse pregnancy outcome

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dc.authoridYener, Cem/0000-0002-3976-4492
dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.contributor.authorYener, Cem
dc.contributor.authorVarol, Fusun
dc.contributor.authorInan, Cihan
dc.contributor.authorSutcu, Havva
dc.contributor.authorAtes, Sinan
dc.contributor.authorSayin, Cenk
dc.date.accessioned2024-06-12T10:51:43Z
dc.date.available2024-06-12T10:51:43Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOur objective is to investigate maternal midtrimester plasma and amniotic fluid (AF) levels of angiopoietin-2 (Ang-2) and thrombomodulin (TM), which are involved in vascular remodelling and endothelium activation, in placental disorders including foetal growth restriction (FGR) and preeclampsia (PE). This prospective multiparametric pilot study was conducted at the Perinatology Division of Trakya University in a population undergoing genetic amniocentesis. Both AF and plasma aliquots were kept in -80 degrees C until ELISA assay. The pregnancies were followed up until the end of gestation in terms of obstetric results. Amniotic fluid and plasma aliquots from 127 pregnancies who underwent genetic amniocentesis between 16 and 24 weeks of gestation were analysed. During the final data evaluation, 39 were excluded with various reasons. Twelve subsequently developed FGR and 11 complicated with PE. The control group (n = 65) was consisted of women delivered >37th week with an uncomplicated outcome. The midtrimester maternal Ang-2 levels in both AF and plasma and also TM levels in plasma were found to be significantly increased in pregnancies who subsequently developed FGR or PE (p< .05). The midtrimester Ang-2, which rises in both plasma and AF and the midtrimester TM, which only significantly increase in plasma compartment in PE group, as compensatory mechanism may be the precursors of placental disorders including FGR and PE.Impact Statement What is already known on this subject? It is known that angiopoietin-2 (Ang-2) has important role in placental angiogenesis and vascular remodelling. TM which is a receptor for Ang-2 plays a protective role in pregnancy by preventing the uteroplacental circulation from thrombosis. What do the results of this study add? The present study demonstrates that both midtrimester maternal plasma Ang-2/TM and amniotic fluid (AF) Ang-2 levels were significantly higher in PE and FGR group than uncomplicated group. Midtrimester AF TM levels were not significantly higher in PE group than the control group. What the implications are of these findings for clinical practice and/or further research? In the clinical practice, high levels of midtrimester Ang-2 and TM in plasma may be used for the prediction of FGR and PE. Although amniocentesis is not practical in the clinical use, the levels of these two markers in both AF and plasma compartments may contribute to explain the pathophysiology of FGR and PE.en_US
dc.description.sponsorshipResearch Fund of the Trakya University [2019/22]en_US
dc.description.sponsorshipThis study was supported by Research Fund of the Trakya University (Project Number: 2019/22).en_US
dc.identifier.doi10.1080/01443615.2021.1960293
dc.identifier.endpage928en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue5en_US
dc.identifier.pmid34693872en_US
dc.identifier.scopus2-s2.0-85118163579en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage923en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2021.1960293
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18465
dc.identifier.volume42en_US
dc.identifier.wosWOS:000710841500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiopoietin-2en_US
dc.subjectFoetal Growth Restrictionen_US
dc.subjectPreeclampsiaen_US
dc.subjectThrombomodulinen_US
dc.subjectExpressionen_US
dc.subjectPreeclampsiaen_US
dc.subjectTie-2en_US
dc.subjectWomenen_US
dc.titleRelationship between second-trimester amniotic fluid and plasma levels of angiopoietin-2 and thrombomodulin with adverse pregnancy outcomeen_US
dc.typeArticleen_US

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