Evaluation of maternal serum hypoxia inducible factor-1, progranulin and syndecan-1 levels in pregnancies with early- and late-onset preeclampsia

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dc.authoridMadazli, Riza/0000-0002-6400-1964
dc.authoridÖzel, Aysegül/0000-0002-0283-1049
dc.authoridAkkaya Fırat, Asuman/0000-0001-7338-3282;
dc.authorwosidMadazli, Riza/AAD-3721-2021
dc.authorwosidMadazlı, Rıza/AAA-8734-2020
dc.authorwosidÖzel, Aysegül/ABL-8427-2022
dc.authorwosidSimsek, Arife/C-7348-2019
dc.authorwosidAkkaya Fırat, Asuman/JAO-5175-2023
dc.authorwosiddavutoglu, ebru alici/AAD-3181-2021
dc.authorwosidAlıcı Davutoğlu, Ebru/AIE-5610-2022
dc.contributor.authorDavutoglu, Ebru Alici
dc.contributor.authorFirat, Asuman Akkaya
dc.contributor.authorOzel, Aysegul
dc.contributor.authorYilmaz, Nevin
dc.contributor.authorUzun, Isil
dc.contributor.authorYuksel, Ilkbal Temel
dc.contributor.authorMadazli, Riza
dc.date.accessioned2024-06-12T10:59:58Z
dc.date.available2024-06-12T10:59:58Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To determine the serum levels of HIF-1 , progranulin, and syndecan-1 in preeclampsia (PE) and normal pregnancy, and to compare whether these markers demonstrate any difference between early-onset PE (EO-PE) and late-onset PE (LO-PE).Methods: This cross-sectional study was conducted on 27 women with EO-PE, 27 women with LO-PE, and 26 healthy normotensive pregnant controls matched for gestational age. Maternal levels of serum HIF-1 , progranulin, and syndecan-1 were measured with the use of an enzyme-linked immunosorbent assay kit.Results: Statistical analysis revealed significant differences between the control and the PE groups in progranulin (p<.001) and syndecan-1 (p<.001) levels. There were no significant differences in the serum HIF-1 levels between these groups (p=.069). When PE patients were evaluated by considering subgroups; statistical analysis revealed significant inter-group differences in all biomarkers. Serum progranulin levels were significantly higher in LO-PE compared with the other two groups (EO-PE versus LO-PE and LO-PE versus controls p=.000). Control group presented significantly higher syndecan-1 levels, than EO and LO-PE (p<.001). HIF-1 levels positively correlated with progranulin levels (r=.439, p=.000).Conclusions: Serum progranulin may have potential to be used as a biomarker for the differentiation of EO-PE and LO-PE. The co-operative action between HIF-1 and progranulin might play a key role in the pathogenesis of LO-PE. The predominant feature of LO-PE seems to be an inflammatory process, whereas in EO-PE placentation problem seems to be the main pathology.en_US
dc.identifier.doi10.1080/14767058.2017.1333098
dc.identifier.endpage1982en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue15en_US
dc.identifier.scopus2-s2.0-85020231270en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1976en_US
dc.identifier.urihttps://doi.org/10.1080/14767058.2017.1333098
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20649
dc.identifier.volume31en_US
dc.identifier.wosWOS:000431709800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEarly-Onset Preeclampsiaen_US
dc.subjectLate-Onset Preeclampsiaen_US
dc.subjectHypoxia-Inducible Factor-1en_US
dc.subjectProgranulinen_US
dc.subjectSyndecan-1en_US
dc.subjectPlacental Developmenten_US
dc.subjectGrowth Restrictionen_US
dc.subjectExpressionen_US
dc.subjectOxygenen_US
dc.subjectStatesen_US
dc.subjectPhaseen_US
dc.titleEvaluation of maternal serum hypoxia inducible factor-1, progranulin and syndecan-1 levels in pregnancies with early- and late-onset preeclampsiaen_US
dc.typeArticleen_US

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