Relationships among iron, protein oxidation and lipid peroxidation levels in rats with alcohol-induced acute pancreatitis

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dc.authoridAydemir, Birsen/0000-0003-1406-864X
dc.authoridUnal, Ethem/0000-0003-4056-4874
dc.authorwosidAydemir, Birsen/HKO-5522-2023
dc.contributor.authorKiziler, Ali Riza
dc.contributor.authorAydemir, Birsen
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorUnal, Ethem
dc.contributor.authorGunes, Pembegul
dc.date.accessioned2024-06-12T11:07:16Z
dc.date.available2024-06-12T11:07:16Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.descriptionNational Surgery Congress -- MAY 24-28, 2006 -- Antalya, TURKEYen_US
dc.description.abstractIt has been previously shown that alcohol induces the damage of pancreatic parenchyma tissue, but the mechanism of this damage is still poorly understood. Assuming that oxygen radical damage may be the involved, we measured markers of oxidative damage in pancreatic tissue, blood serum, plasma, and whole blood of rats with early-stage alcohol-induced acute pancreatitis. Thirty-eight male Wistar rats were divided into three groups: the control group (group 1), the acute pancreatitis group 1 day (group 2), and 3 days (group 3) after the injection of ethyl alcohol into the common biliary duct, respectively. The levels of Fe in tissue and serum, whole blood viscosity, plasma viscosity, fibrinogen and homocysteine (Hcy) levels, erythrocyte and plasma malondialdehyde (MDA), and tissue and plasma protein carbonyl levels were found to be significantly higher in groups 2 and 3 than in group 1. However, the levels of reduced glutathione (GSH) in tissue and erythrocytes were significantly lower in groups 2 and 3 than in group 1. These results suggest that elevated Fe levels in serum and pancreatic tissue in rats with early-stage alcohol-induced acute pancreatitis is associated with various hemorheological changes and with oxidative damage of the pancreas.en_US
dc.identifier.doi10.1007/s12011-008-8127-6
dc.identifier.endpage143en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid18408897en_US
dc.identifier.scopus2-s2.0-55549104403en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-008-8127-6
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21977
dc.identifier.volume124en_US
dc.identifier.wosWOS:000259003900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIronen_US
dc.subjectHomocysteineen_US
dc.subjectMalondialdehydeen_US
dc.subjectProtein Carbonylsen_US
dc.subjectViscosityen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectHydrogen Peroxideen_US
dc.subjectFree-Radicalsen_US
dc.subjectStressen_US
dc.subjectInjuryen_US
dc.subjectPathophysiologyen_US
dc.subjectGlutathioneen_US
dc.subjectMechanismen_US
dc.subjectViscosityen_US
dc.subjectTissuesen_US
dc.subjectDamageen_US
dc.titleRelationships among iron, protein oxidation and lipid peroxidation levels in rats with alcohol-induced acute pancreatitisen_US
dc.typeConference Objecten_US

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