Cytotoxicity of doxrubicin loaded single-walled carbon nanotubes

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dc.authoridMeran, Mehdi/0000-0001-8804-1365
dc.authoridGüner, F. Seniha/0000-0002-3414-4868
dc.authoridKaratepe, Nilgün/0000-0002-7392-4103
dc.authoridDinc, Bircan/0000-0002-9717-6410
dc.authoridunlu, ayhan/0000-0001-6033-7148
dc.authorwosidBektaş, Muhammet/AAE-5503-2020
dc.authorwosidMeran, Mehdi/HKN-2401-2023
dc.authorwosidGüner, F. Seniha/ABF-7949-2020
dc.authorwosidKaratepe, Nilgün/AAK-5641-2020
dc.authorwosidDinc, Bircan/ADG-4955-2022
dc.authorwosidunlu, ayhan/Q-1843-2016
dc.contributor.authorUnlu, Ayhan
dc.contributor.authorMeran, Mehdi
dc.contributor.authorDinc, Bircan
dc.contributor.authorKaratepe, Nilgun
dc.contributor.authorBektas, Muhammet
dc.contributor.authorGuner, F. Seniha
dc.date.accessioned2024-06-12T11:14:10Z
dc.date.available2024-06-12T11:14:10Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCarbon nanotube (CNTs) is a new alternative for efficient drug delivery and it has a great potential to change drug delivery system profile in pharmaceutical industry. One of the important advantage of CNTs is their needle-like, cylindrical shape. This shape provides a high surface area for multiple connections and adsorption onto for millions of therapeutic molecules. CNTs can be internalized by cells via endocytosis, passive diffusion and phagocytosis and release the drug with different effects like pH and temperature. The acidic nature of cancer cells and the susceptibility of CNTs to release the drug in the acidic environment have made it a promising area of research in cancer drug delivery. In this research, we investigated cell viability, cytotoxicity and drug delivery in breast cancer cell line by designing non-covalent single walled carbon nanotubes (SWNT)-doxorubicin (DOX) supramolecular complex that can be developed for cancer therapy. Applied high concentrations of DOX loaded SWNTs changed the actin structure of the cells and prevented the proliferation of the cells. It was showed that doxorubicin loaded SWNTs were more effective than free doxorubicin at relatively small concentrations. Once we applied same procedure for short and long (short: 1-1.3 mu m; long: 2.5-4 mu m) SWNTs and compared the results, more disrupted cell structure and reduction in cell proliferation were observed for long CNTs. DOX is bounded more to nanotubes in basic medium, less bound in acidic environment. Cancer cells were also examined for concentration at which they were effective by applying DOX and it was seen that 3.68 mu M doxorubicin kills more than 55% of the cells.en_US
dc.identifier.doi10.1007/s11033-018-4189-5
dc.identifier.endpage531en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue4en_US
dc.identifier.pmid29797174en_US
dc.identifier.scopus2-s2.0-85047347759en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage523en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-018-4189-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23828
dc.identifier.volume45en_US
dc.identifier.wosWOS:000439948500012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSingle-Walled Carbon Nanotubesen_US
dc.subjectDoxorubicinen_US
dc.subjectNanotechnologyen_US
dc.subjectCytotoxicityen_US
dc.subjectMDA-MB-231en_US
dc.subjectCancer-Cell-Linesen_US
dc.subjectBreast-Canceren_US
dc.subjectDoxorubicinen_US
dc.subjectDeliveryen_US
dc.subjectTherapyen_US
dc.titleCytotoxicity of doxrubicin loaded single-walled carbon nanotubesen_US
dc.typeArticleen_US

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