Oxidative Stress and Testicular Torsion
Küçük Resim Yok
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Testicular torsion is a medical urologic syndrome that constitutes a surgical emergency affecting newborns, children, and adolescent boys. The main pathophysiological event in testicular torsion is ischemia (torsion) followed by reperfusion (detorsion) of the testis, and multifactorial mechanisms seem to mediate this condition. Testicular damage after ischemia/reperfusion (I/R) is related to the duration of ischemia and to the severity of the torsion. I/R injury is associated with activation of neutrophils, inflammatory cytokines, and adhesion molecules with increased thrombogenicity, release of massive intracellular calcium, and overgeneration of reactive oxygen species and reactive nitrogen species. Although the results are not conclusive and the molecular mechanism by which antioxidants control male fertility have not yet been clearly identified, several antioxidant enzymes and antioxidant drugs have been studied to prevent such I/R injury in testis. Antioxidant therapy may represent a new option within a broader therapeutic strategy in testicular torsion with oxidative stress-mediated infertility.
Açıklama
Anahtar Kelimeler
Antioxidant, Ischemia/Reperfusion, Lipid Peroxidation, Male Infertility, Oxidative Stress, Reactive Oxygen/Nitrogen Species, Testicular Torsion, Ischemia-Reperfusion Injury, Spermatic Cord Torsion, Antioxidant Enzyme-Activities, Activated Protein-Kinases, Endothelial Growth-Factor, Cell-Adhesion Molecules, Term Histologic Damage, Nitric-Oxide Synthase, Phenethyl Ester Cape, Alpha-Lipoic Acid
Kaynak
Studies On Mens Health And Fertility
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
