Effect of Local Polyhexanide Application in Preventing Exit-Site Infection and Peritonitis: A Randomized Controlled Trial

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dc.authoridkurultak, ilhan/0000-0001-5607-1375
dc.authoridDuranay, Murat/0000-0002-2893-4484
dc.authorwosidUnverdi, Selman/B-7021-2019
dc.authorwosidkurultak, ilhan/V-1616-2019
dc.authorwosidDuranay, Murat/HKV-1804-2023
dc.contributor.authorCeri, Mevlut
dc.contributor.authorYilmaz, Seref Rahmi
dc.contributor.authorUnverdi, Selman
dc.contributor.authorKurultak, Ilhan
dc.contributor.authorDuranay, Murat
dc.date.accessioned2024-06-12T11:01:35Z
dc.date.available2024-06-12T11:01:35Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTopical antibiotic and antiseptic agents have been documented to reduce exit-site infection (ESI) and peritonitis in PD. The aim of this randomized controlled study was to evaluate the efficacy of polyhexanide in the prevention of ESI and peritonitis. Patients were excluded if they had active infection, > 18 years of age, ESI and peritonitis within the previous 4 weeks, received PD for less than 3-months and history of allergy to either drug. All patients were followed up until catheter removal, death, switch to dialysis, transplantation or the end of the study. ESI, tunnel infection, peritonitis, catheter removal and microorganism cause of catheter-related infection were recorded prospectively during clinic follow-up. A total of 88 patients (41 povidone-iodine group; 47 polyhexanide group) were enrolled with a total follow-up duration of 480 and 555 patient-months for povidone-iodine and alternating group, respectively. There were no significant differences in the age, sex, BMI, time of PD, rate of DM, and S. aureus carriage state. A total of 8 ESI and 25 peritonitis episodes were detected during the study. ESI and peritonitis rates tended to be lower in polyhexanide group compared with the povidone-iodine group (0.06 episodes/patient-year vs. 0.12 episodes/patient-year; 0.26 episodes/patient-year vs. 0.32 episodes/patient-year, respectively), but were not significant statistically. Moreover, catheter removal was similar in both groups (0.04 / patient-year vs. 0.05 / patient-year). Polyhexanide is efficient and safe for the prevention of ESI and peritonitis and it may be used as an alternative procedure for the care of healthy exit sites.en_US
dc.identifier.doi10.1111/1744-9987.12836
dc.identifier.endpage84en_US
dc.identifier.issn1744-9979
dc.identifier.issn1744-9987
dc.identifier.issue1en_US
dc.identifier.pmid31066988en_US
dc.identifier.scopus2-s2.0-85068658847en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.1111/1744-9987.12836
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20959
dc.identifier.volume24en_US
dc.identifier.wosWOS:000505279700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofTherapeutic Apheresis And Dialysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExit-Site Infectionen_US
dc.subjectPeritoneal Dialysisen_US
dc.subjectPeritonitisen_US
dc.subjectPolyhexanideen_US
dc.subjectDialysis-Related Infectionsen_US
dc.subjectTopical Mupirocinen_US
dc.subjectCatheteren_US
dc.subjectEfficacyen_US
dc.subjectSafetyen_US
dc.subjectRecommendationsen_US
dc.subjectGentamicinen_US
dc.titleEffect of Local Polyhexanide Application in Preventing Exit-Site Infection and Peritonitis: A Randomized Controlled Trialen_US
dc.typeArticleen_US

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