Malignant Ovarian Germ Cell Tumors A Single-Institution Experience

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dc.authoridKebudi, Rejin/0000-0003-4344-8174
dc.authoridEralp, Yesim/0000-0001-9603-4755
dc.authoridCicin, Irfan/0000-0002-7584-3868;
dc.authorwosidKebudi, Rejin/AAD-8047-2020
dc.authorwosidEralp, Yesim/AAD-7194-2020
dc.authorwosidCicin, Irfan/AAQ-5575-2020
dc.authorwosidKebudi, Rejin/H-8974-2019
dc.authorwosidSaip, pınar/AAT-1500-2020
dc.authorwosidGorgun, Omer/AAD-7978-2020
dc.contributor.authorCicin, Irfan
dc.contributor.authorEralp, Yesim
dc.contributor.authorSaip, Pinar
dc.contributor.authorAyan, Inci
dc.contributor.authorKebudi, Rejin
dc.contributor.authorIyibozkurt, Cem
dc.contributor.authorTuzlali, Sitki
dc.date.accessioned2024-06-12T11:11:51Z
dc.date.available2024-06-12T11:11:51Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To evaluate the clinicopathologic prognostic factors in malignant ovarian genii Cell tumors. Methods: We reviewed the medical records of 70 patients treated from 1990 to 2006 at our center. Clinical data including demographics, stage, surgery, chemotherapy, survival, menses status, and fertility were collected from patients' charts. Results: Median age was 22 years (range, 9-68). The histologic Subtypes included 36 dysgerminomas, 11 yolk sac tumors, 3 immature teratomas, 1 embryonal carcinomas, and 19 mixed types. The most striking clinicopathologic finding was a history of concomitant immunosuppressant therapy, which was observed in 2 patients. Two patients had contralateral sex-cord tumors at presentation and follow-up. During a median follow-tip period of 4.6 years, 11 patients had recurrence. The median time to recurrence was 8 months (6-28 months). Recurrences appeared in the abdominopelvic cavity in 9 Out Of 11 patients. Only one could be salvaged with second-line chemotherapy. Cumulative survival rate was 97% and 60% in patients with dysgerminoma and nondysgerminoma, respectively. Nondysgerminoma histology and residual tumor after surgery were unfavorable prognostic factors (P < 0.001 and P = 0.015). Fertility-sparing surgery was as effective as radical surgery among all eligible patients. Of patients with known menstrual status, 96% had regular menses. Of the 8 patients who opted for conception among these patients, 7 delivered healthy infants. Conclusions: Nondysgerminomas have an aggressive clinical course. New treatment strategies are needed for eradication of abdominopelvic disease at initial diagnosis and recurrent setting. Occurrence of malignant ovarian germ cell tumors may be associated with immunosuppression in some patients. Sex-cord stromal tumors may present with bilateral involvement. It is possible to maintain fertility after fertility-sparing surgery followed by chemotherapy.en_US
dc.identifier.doi10.1097/COC.0b013e3181841f2e
dc.identifier.endpage196en_US
dc.identifier.issn0277-3732
dc.identifier.issue2en_US
dc.identifier.pmid19307952en_US
dc.identifier.scopus2-s2.0-67749148917en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage191en_US
dc.identifier.urihttps://doi.org/10.1097/COC.0b013e3181841f2e
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22960
dc.identifier.volume32en_US
dc.identifier.wosWOS:000265056900016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal Of Clinical Oncology-Cancer Clinical Trialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOvarian Germ Cell Turneren_US
dc.subjectPrognosisen_US
dc.subjectFertilityen_US
dc.subjectImmunosuppressionen_US
dc.subjectEndodermal Sinus Tumoren_US
dc.subjectPrognostic-Factorsen_US
dc.subjectChemotherapyen_US
dc.subjectInfectionen_US
dc.subjectPregnancyen_US
dc.subjectTeratomaen_US
dc.titleMalignant Ovarian Germ Cell Tumors A Single-Institution Experienceen_US
dc.typeArticleen_US

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