The impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor response

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dc.authoridZhou, Su-Min/0000-0002-7517-9653
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.contributor.authorMao, Jingfang
dc.contributor.authorKocak, Zafer
dc.contributor.authorZhou, Sumin
dc.contributor.authorGarst, Jennifer
dc.contributor.authorEvans, Elizabeth S.
dc.contributor.authorZhang, Junan
dc.contributor.authorLarrier, Nicole A.
dc.date.accessioned2024-06-12T11:13:21Z
dc.date.available2024-06-12T11:13:21Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description47th Annual Meeting of the American-Society-for-Therapeutic-Radiology-and-Oncology -- OCT 16-20, 2005 -- Denver, COen_US
dc.description.abstractPurpose: To assess the impact of induction chemotherapy, and associated tumor shrinkage, on the subsequent radiation-related changes in pulmonary function and tumor response. Methods and Materials: As part of a prospective institutional review board-approved study, 91 evaluable patients treated definitively with thoracic radiation therapy (RT) for unresectable lung cancer were analyzed. The rates of RT-associated pulmonary toxicity and tumor response were compared in the patients with and without pre-RT chemotherapy. In the patients receiving induction chemotherapy, the rates of RT-associated pulmonary toxicity and tumor response were compared in the patients with and without a response (modified Response Evaluation Criteria in Solid Tumor criteria) to the pre-RT chemotherapy. Comparisons of the rates of improvements in pulmonary function tests (PFTs) post-RT, dyspnea requiring steroids, and percent declines in PFTs post-RT were compared in patient subgroups using Fisher's exact test, analysis of variance, and linear or logistic regression. Results: The use of pre-RT chemotherapy appears to increase the rate of radiation-induced pneumonitis (p 0.009-0.07), but has no consistent impact on changes in PFTs. The degree of induction chemotherapy-associated tumor shrinkage is not associated with the rate of subsequent RT-associated pulmonary toxicity. The degree of tumor response to chemotherapy is not related to the degree of tumor response to RT. Conclusions: Additional study is needed to better clarify the impact of chemotherapy on radiation-associated disfunction. (c) 2007 Elsevier Inc.en_US
dc.description.sponsorshipAmer Soc Therapeut Radiol & Oncolen_US
dc.description.sponsorshipNCI NIH HHS [R01 CA069579, R29 CA069579, R01-CA69579] Funding Source: Medlineen_US
dc.identifier.doi10.1016/j.ijrobp.2006.11.003
dc.identifier.endpage1369en_US
dc.identifier.issn0360-3016
dc.identifier.issue5en_US
dc.identifier.pmid17276621en_US
dc.identifier.scopus2-s2.0-33947526082en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1360en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijrobp.2006.11.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23509
dc.identifier.volume67en_US
dc.identifier.wosWOS:000245567500010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofInternational Journal Of Radiation Oncology Biology Physicsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRadiation-Induced Pneumonitisen_US
dc.subjectPulmonary Function Testsen_US
dc.subjectTumor Responseen_US
dc.subjectInduction Chemotherapyen_US
dc.subjectLung Canceren_US
dc.subjectConformal Therapy Consortiumen_US
dc.subjectVolume Histogram Analysisen_US
dc.subjectPulmonary-Function Testsen_US
dc.subjectDose-Escalation Trialen_US
dc.subjectCancer-Patientsen_US
dc.subjectBreast-Canceren_US
dc.subjectThoracic Irradiationen_US
dc.subjectRisk-Factorsen_US
dc.subjectFollow-Upen_US
dc.subjectPneumonitisen_US
dc.titleThe impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor responseen_US
dc.typeConference Objecten_US

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