Risk factors of status epilepticus in children

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dc.contributor.authorKarasalihoglu, S
dc.contributor.authorÖner, N
dc.contributor.authorÇeltik, C
dc.contributor.authorÇelik, Y
dc.contributor.authorBiner, B
dc.contributor.authorUtku, U
dc.date.accessioned2024-06-12T10:56:18Z
dc.date.available2024-06-12T10:56:18Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground : Although there is abundant literature about the morbidity and mortality rates of status epilepticus (SE), little is known about the risk factors of this medical emergency. The aim of the present study is to assess the risk factors of SE in children. Methods : The authors reviewed the medical records of 83 patients admitted to the Pediatric Neurology Unit of Trakya University Hospital, Edirne, Turkey from January 1994 to December 2001 with the diagnosis of SE. Eighty-three patients were compared with 166 controls who were admitted to the same unit due to non-status epilepticus (non-SE) seizure. Results : The univariate analysis demonstrated that SE episodes were significantly associated with a history of birth asphyxia, neonatal seizure, discontinuation of antiepileptic medication, epilepsy, partial seizure evolving to secondary generalized seizures, myoclonic seizure, generalized abnormalities in the neurological examination, neuromotor retardation, generalized background abnormalities on electroencephalogram (EEG), generalized abnormalities on neuroimaging and polypharmacy than non-SE episodes. Logistic regression was used to test the independence of these parameters as predictors of SE risk. Four parameters emerged as significant independent predictors of SE in children in multiple logistic regression: polypharmacy (Odds ratio (OR) 5.17, P = 0.0004), discontinuation of antiepileptic medication (OR 4.04, P = 0.0095), neuromotor retardation (OR 4.03, P = 0.0016) and generalized background abnormalities on EEG (OR 2.48, P = 0.0419). Conclusion : Polypharmacy, discontinuation of antiepileptic medication, neuromotor retardation and generalized background abnormalities on EEG are indicators in children of a higher risk of SE.en_US
dc.identifier.doi10.1046/j.1442-200X.2003.01758.x
dc.identifier.endpage434en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue4en_US
dc.identifier.pmid12911480en_US
dc.identifier.scopus2-s2.0-0141742687en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage429en_US
dc.identifier.urihttps://doi.org/10.1046/j.1442-200X.2003.01758.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19746
dc.identifier.volume45en_US
dc.identifier.wosWOS:000184662800012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectRisk Factorsen_US
dc.subjectStatus Epilepticusen_US
dc.subjectMortalityen_US
dc.titleRisk factors of status epilepticus in childrenen_US
dc.typeArticleen_US

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