Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats

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dc.authoridGurcan, Saban/0000-0002-5052-481X
dc.authorwosidOguz, Serhat/HKE-2793-2023
dc.authorwosidGurcan, Saban/D-2754-2017
dc.contributor.authorHatipoglu, Ahmet Rahmi
dc.contributor.authorOguz, Serhat
dc.contributor.authorGurcan, Saban
dc.contributor.authorYalta, Tulin
dc.contributor.authorAlbayrak, Dogan
dc.contributor.authorErenoglu, Cengiz
dc.contributor.authorSagiroglu, Tamer
dc.date.accessioned2024-06-12T10:54:09Z
dc.date.available2024-06-12T10:54:09Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced. Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model. Study Design: Animal experimentation. Methods: Forty adult, male, Sprague Dawley rats were used in this study. Animals were randomised and divided into five groups of eight each: sham (Sh); control (common bile duct ligation, CBDL); and supplementation groups administered tauroursodeoxycholic acid (CBDL+T), glutamine (CBDL+G), or tauroursodeoxycholic acid plus glutamine (CBDL+TG). Blood and liver, spleen, MLN, and ileal samples were taken via laparotomy under sterile conditions for investigation of bacterial translocation and intestinal mucosal integrity and hepatic function tests on the tenth postoperative day. Results: There were statistically significant differences in BT rates in all samples except the spleen of the CBDL+TG group compared with the CBDL group (p=0.041, p=0.026, and p=0.041, respectively). Conclusion: It is essential to protect hepatic functions besides maintaining intestinal mucosal integrity in the active struggle against BT occurring in obstructive jaundice. The positive effect on intestinal mucosal integrity can be increased if glutamine is used with tauroursodeoxycholic acid, which also has hepatoprotective and immunomodulatory features.en_US
dc.identifier.doi10.5152/balkanmedj.2013.7785
dc.identifier.endpage368en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.pmid25207142en_US
dc.identifier.scopus2-s2.0-84891592417en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage362en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2013.7785
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18950
dc.identifier.volume30en_US
dc.identifier.wosWOS:000329206300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBacterial Translocationen_US
dc.subjectGlutamineen_US
dc.subjectTauroursodeoxycholic Aciden_US
dc.subjectIncreased Intestinal Permeabilityen_US
dc.subjectGut-Barrieren_US
dc.subjectUrsodeoxycholic Aciden_US
dc.subjectBiliary-Cirrhosisen_US
dc.subjectOxidative Stressen_US
dc.subjectBile-Aciden_US
dc.subjectLiveren_US
dc.subjectDysfunctionen_US
dc.subjectApoptosisen_US
dc.subjectImmunonutritionen_US
dc.titleCombined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Ratsen_US
dc.typeArticleen_US

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