The effect of L-lysine on serum sialic acid levels in isoproterenol-induced myocardial infarction in rats

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dc.contributor.authorUzgur, Selda
dc.contributor.authorUsta, Ufuk
dc.contributor.authorGoekmen, Selma Sueer
dc.date.accessioned2024-06-12T11:07:45Z
dc.date.available2024-06-12T11:07:45Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: To investigate the effect of L-lysine on serum total and lipid-bound sialic acid levels in isoproterenol-induced myocardial infarction and to evaluate the role of cell damage in the elevation of sialic acid post-infarction. Material and Methods: Male albino rats of Wistar strain were divided into three groups randomly: control, isoproterenol and isoproterenol+L-lysine. Myocardial infarction was produced with 150 mg/kg of isoproterenol administered intraperitoneally twice at an interval of 24 hour. L-Lysine was given orally (5 mg/kg/day) for 5 days. Existence of experimental infarction was confirmed by histopathological changes and the elevation of troponin I. The levels of serum total and lipid-bound sialic acid were determined by the methods of Warren and Katopodis, respectively. Results: Isoproterenol caused a significant elevation in serum troponin I, total and lipid-bound sialic acid levels and a prominent atrophy and fibrotic changes confirming myocardial infarction in heart tissue. L-Lysine significantly prevented troponin I, total and lipid-bound sialic acid increase in serum and atrophy and connective tissue development in heart tissue. Conclusion: Cell damage may play an important role in serum sialic acid elevation after myocardial infarction. Conflict of interest: The authors have no conflict of interest.en_US
dc.identifier.endpage254en_US
dc.identifier.issn0250-4685
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84858227291en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage248en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22177
dc.identifier.volume36en_US
dc.identifier.wosWOS:000300974400010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkish Biochem Socen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectL-Lysineen_US
dc.subjectTotal And Lipid-Bound Sialic Aciden_US
dc.subjectTroponin Ien_US
dc.subjectExperimental Myocardial Infarctionen_US
dc.subjectCell Damageen_US
dc.subjectAcute-Phase Proteinsen_US
dc.subjectL-Arginineen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectUrea Cycleen_US
dc.subjectArginaseen_US
dc.subjectDamageen_US
dc.subjectCellsen_US
dc.subjectInflammationen_US
dc.subjectReperfusionen_US
dc.subjectMetabolismen_US
dc.titleThe effect of L-lysine on serum sialic acid levels in isoproterenol-induced myocardial infarction in ratsen_US
dc.typeArticleen_US

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