Protective effects of vitamin C on cisplatin-induced renal damage: A light and electron microscopic study

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dc.contributor.authorTarladacalisir, Yeter Topcu
dc.contributor.authorKanter, Mehmet
dc.contributor.authorUygun, Muberra
dc.date.accessioned2024-06-12T10:56:35Z
dc.date.available2024-06-12T10:56:35Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe present study was performed to investigate whether the chronic administration of antioxidant vitamin C provided morphological protection on cisplatin-induced renal damage. Wistar albino male rats were divided into control and two experiment groups, each consisting of six rats. Cisplatin (5 mg/kg/month) was administered intravenously to the second and third group for three months. After the first application of cisplatin, vitamin C (8 mg/kg/day) to the third group was administered intramuscular for 3 months. At the end of the third month, the kidney specimens of the all groups were obtained. All of these kidney specimens were processed for light and electron microscopical examination. In the second group, most of the renal corpuscle lost their normal appearance and size, especially in the corticomedullary region. The most obvious changes were encountered in the proximal tubules. These changes were tubular dilation, thickening of basement membrane, loss of brush border, vacuolization, and swollenness of mitochondria in the proximal tubule epithelial cells. In addition, infiltration foci were observed mainly in the cortical region. In the third group, which was administered cisplatin plus vitamin C, although the structural damages and morphometric changes were lessened, mononuclear cell infiltration was still observed. This study suggests that the chronic administration of vitamin C may be of therapeutic benefit on cisplatin nephrotoxicity.en_US
dc.identifier.doi10.1080/08860220701742070
dc.identifier.endpage8en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue1en_US
dc.identifier.pmid18197536en_US
dc.identifier.scopus2-s2.0-38148999548en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/08860220701742070
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19844
dc.identifier.volume30en_US
dc.identifier.wosWOS:000252405700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectNephrotoxicityen_US
dc.subjectVitamin Cen_US
dc.subjectMorphometryen_US
dc.subjectRaten_US
dc.subjectInduced Nephrotoxicityen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectAntioxidants Curcuminen_US
dc.subjectOxidative Stressen_US
dc.subjectRaten_US
dc.subjectToxicityen_US
dc.subjectSeleniumen_US
dc.subjectProoxidanten_US
dc.subjectKidneysen_US
dc.subjectCellsen_US
dc.titleProtective effects of vitamin C on cisplatin-induced renal damage: A light and electron microscopic studyen_US
dc.typeArticleen_US

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