Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)

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dc.authoridCarman, Kursat Bora/0000-0002-4629-1873
dc.authoridYue, Yuhang/0000-0003-1941-7677
dc.authoridNUHOĞLU, ÇAĞATAY/0000-0003-2187-4121
dc.authoridCALIK, Mustafa/0000-0001-9963-5724
dc.authoridYazar, Ahmet Sami/0000-0001-7624-3410
dc.authoridkocak, ozan/0000-0002-2285-7983
dc.authoridlaçinel gürlevik, sibel/0000-0001-9434-3597
dc.authorwosidCarman, Kursat Bora/V-6663-2017
dc.authorwosidYue, Yuhang/AAW-9279-2021
dc.authorwosidNUHOĞLU, ÇAĞATAY/A-3223-2019
dc.authorwosidCALIK, Mustafa/Q-8105-2019
dc.authorwosidYazar, Ahmet Sami/S-2151-2018
dc.authorwosidkocak, ozan/P-7729-2015
dc.authorwosidYarar, Coskun/D-5545-2018
dc.contributor.authorCarman, Kursat Bora
dc.contributor.authorCalik, Mustafa
dc.contributor.authorKaral, Yasemin
dc.contributor.authorIsikay, Sedat
dc.contributor.authorKocak, Ozan
dc.contributor.authorOzcelik, Aysima
dc.contributor.authorYazar, Ahmet Sami
dc.date.accessioned2024-06-12T10:56:17Z
dc.date.available2024-06-12T10:56:17Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures occurring in their children. There are no routine recommendation to detect etiological causes of FS for neurological perspective, further knowledge about the etiological causes of FS in children will support preventive measures and follow-up strategies. The aim of this study is to evaluate the percentage of respiratory viruses in children with FS. Methods: This prospective multicenter study, entitled Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study) examined representative populations in eight different cities in Turkey between March 1, 2016 and April 1, 2017. Nasopharyngeal swabs were taken from all children at presentation. A respiratory multiplex array was performed to detect for influenza A and B; respiratory syncytial virus A and B; human parainfluenza virus 1-2-3 and 4; human coronavirus 229E and OC43; human rhinovirus; human enterovirus; human adenovirus; human bocavirus; human metapneumovirus. Results: During the study period, at least one virus was detected in 82.7% (144/174) of children with FS. The most frequently detected virus was adenovirus, followed by influenza A and influenza B. Detection of more than one virus was present in 58.3% of the children with FS, and the most common co-existence was the presence of adenovirus and influenza B. In children younger than 12 months, Coronavirus OC43 was the most common, while influenza A was most frequently observed in children older than 48 months (p ). Human bocavirus was common in children who experienced complex FS, while respiratory syncytial virus (RSV) A was more common in children who experienced simple FS. Influenza B virus was the most common virus identified in children who were experiencing their first incidence of FS (p ). Conclusions: This study indicates that respiratory viruses are important in the etiology of FS in children. The results show that antibiotics must be prescribed carefully in children with FS since the majority of cases are related to viral causes. Widespread use of the existing quadrivalent influenza vaccine might be useful for the prevention of FS related to the flu. Further vaccine candidates for potential respiratory pathogens, including RSV, might be helpful for the prevention of FS.en_US
dc.description.sponsorshipEskisehir Osmangazi Universityen_US
dc.description.sponsorshipThis study has been supported by a research grant from Eskisehir Osmangazi University.en_US
dc.identifier.doi10.1080/21645515.2018.1526588
dc.identifier.endpage502en_US
dc.identifier.issn2164-5515
dc.identifier.issn2164-554X
dc.identifier.issue2en_US
dc.identifier.pmid30235060en_US
dc.identifier.scopus2-s2.0-85054510388en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage496en_US
dc.identifier.urihttps://doi.org/10.1080/21645515.2018.1526588
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19742
dc.identifier.volume15en_US
dc.identifier.wosWOS:000461231000031en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofHuman Vaccines & Immunotherapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectFebrile Seizureen_US
dc.subjectInfectionen_US
dc.subjectRespiratory Virusen_US
dc.subjectInfluenzaen_US
dc.subjectRSVen_US
dc.subjectChildrenen_US
dc.subjectPreventionen_US
dc.subjectInfectionen_US
dc.subjectInfluenzaen_US
dc.subjectVirusesen_US
dc.titleViral etiological causes of febrile seizures for respiratory pathogens (EFES Study)en_US
dc.typeArticleen_US

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