Bicalutamide-associated hallucinations in a metastatic prostate cancer patient: A case report

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dc.authoridTürkkan, Görkem/0000-0002-9084-2599
dc.authorwosidTürkkan, Görkem/AAM-6705-2021
dc.authorwosiddogan, caner/JSL-1129-2023
dc.authorwosidTürkkan, Görkem/E-7048-2017
dc.contributor.authorTurkkan, Gorkem
dc.contributor.authorDogan, Caner
dc.contributor.authorTek, Burak
dc.date.accessioned2024-06-12T10:54:27Z
dc.date.available2024-06-12T10:54:27Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction Bicalutamide is widely used in the treatment of prostate cancer. Among its side effects, central nervous system disorders are relatively rare, and the information about bicalutamide-associated hallucinations is limited. Case report We report an uncommon case of a patient with metastatic prostate cancer, who had hallucinations due to the use of bicalutamide. Management and outcome The patient accepted to receive only hormonal therapy (bicalutamide and leuprolide acetate). But he developed hallucinations due to bicalutamide use. His hallucinations disappeared after discontinuation of bicalutamide. A good response was obtained with the use of luteinizing hormone-releasing hormone agonist monotherapy. Discussion The pathophysiology of bicalutamide-induced hallucinations is unclear. We hypothesize that antiandrogens can indirectly cause hallucinations through changes in plasma testosterone and cerebral reelin expression. Additionally, luteinizing hormone-releasing hormone agonist monotherapy is a good option in metastatic prostate cancer patients who have intolerable side effects due to the use of antiandrogens.en_US
dc.identifier.doi10.1177/1078155219886918
dc.identifier.endpage1031en_US
dc.identifier.issn1078-1552
dc.identifier.issn1477-092X
dc.identifier.issue4en_US
dc.identifier.pmid31707924en_US
dc.identifier.startpage1029en_US
dc.identifier.urihttps://doi.org/10.1177/1078155219886918
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19061
dc.identifier.volume26en_US
dc.identifier.wosWOS:000496089500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of Oncology Pharmacy Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBicalutamideen_US
dc.subjectHallucinationsen_US
dc.subjectProstate Canceren_US
dc.subjectAndrogen Deprivation Therapyen_US
dc.subjectReelinen_US
dc.titleBicalutamide-associated hallucinations in a metastatic prostate cancer patient: A case reporten_US
dc.typeArticleen_US

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