Relationship between serum sialic acids, sialic acid-rich inflammation-sensitive proteins and cell damage in patients with acute myocardial infarction

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dc.contributor.authorGökmen, SS
dc.contributor.authorKazezoglu, C
dc.contributor.authorSunar, B
dc.contributor.authorÖzçelik, F
dc.contributor.authorGüngör, Ö
dc.contributor.authorYorulmaz, F
dc.contributor.authorGülen, S
dc.date.accessioned2024-06-12T10:56:00Z
dc.date.available2024-06-12T10:56:00Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe role of sialic acid ( SA) in the pathogenesis of atherosclerosis and as a predictor of cardiovascular events has attracted much attention in recent years. However, most studies investigating the role of total and lipid-bound sialic acids ( TSA and LSA) in the pathogenesis of atherosclerosis lack information on the reason for the elevated SA concentrations in coronary heart disease and myocardial infarction. Since the inflammation-sensitive proteins are glycoproteins with SA residues, an increase in their levels due to some type of acute-phase reaction or inflammation could be responsible for the elevated TSA levels in acute myocardial infarction ( AMI). Elevated serum SA levels might also be due to either shedding or secretion of free SA from the cell or cell membrane surface if neuraminidase levels are increased, or to the release of cellular SA-containing glycolipids and/ or glycoproteins into plasma from myocardial cells after AMI. The aim of the present study was to investigate both the possible role of SA-rich inflammation-sensitive proteins and the cell damage due to elevated serum TSA levels in AMI. A possible role of serum LSA as an indicator of the shedding or secretion of SA from the cell or cell membrane surface in AMI was also evaluated. The study included 38 subjects with AMI and 32 healthy volunteers. Serum TSA and LSA were determined using the methods of Warren and Katopodis, respectively. The concentrations of serum SA-rich inflammation-sensitive proteins, namely alpha(1)-antitrypsin, alpha(2)-macroglobulin and ceruloplasmin were determined immunoturbidimetrically. Our data showed that: a) mean levels of serum TSA and LSA and SA-rich inflammation-sensitive proteins in patients with AMI were significantly increased; and b) there was a significant positive correlation between TSA and LSA and alpha(1)-antitrypsin in patients with AMI. Since the transfer of free SA to lipoproteins is required for an increase in serum LSA levels, and free SA for this transfer can be provided by the secretion of SA from the cell, it is obvious that the shedding or secretion of SA from the cell membrane surface or release of cellular SA from cells into the bloodstream due to cell damage after AMI also occur after AMI. As a result, we can report that either the shedding or secretion of SA from the cell or cell membrane surface and the increased output of SA-rich inflammation-sensitive proteins may together be responsible for the elevated TSA levels in AMI.en_US
dc.identifier.doi10.1515/CCLM.2006.037
dc.identifier.endpage206en_US
dc.identifier.issn1434-6621
dc.identifier.issn1437-4331
dc.identifier.issue2en_US
dc.identifier.pmid16475908en_US
dc.identifier.scopus2-s2.0-32544448989en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.1515/CCLM.2006.037
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19633
dc.identifier.volume44en_US
dc.identifier.wosWOS:000235777200014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofClinical Chemistry And Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell Damageen_US
dc.subjectLipid-Bound Sialic Aciden_US
dc.subjectMyocardial Infarctionen_US
dc.subjectSialic Acid-Rich Inflammation-Sensitive Proteinsen_US
dc.subjectTotal Sialic Aciden_US
dc.subjectAcute-Phase Proteinsen_US
dc.subjectCoronary-Arteryen_US
dc.subjectAtherosclerosisen_US
dc.subjectSialylationen_US
dc.subjectMetabolismen_US
dc.subjectAnginaen_US
dc.titleRelationship between serum sialic acids, sialic acid-rich inflammation-sensitive proteins and cell damage in patients with acute myocardial infarctionen_US
dc.typeArticleen_US

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