Investigation of TNF-?, LT-? and TNFR-2 gene Polymorphisms in Patients with Periodontitis in Turkey

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dc.authoridDursun, Erhan/0000-0003-2137-8638
dc.authoridÖzkan-Kotiloğlu, Selin/0000-0002-2262-5613
dc.authorwosidDursun, Erhan/JWO-7302-2024
dc.authorwosidGuncu, Guliz N/G-2394-2018
dc.authorwosidÖzkan-Kotiloğlu, Selin/ABB-9677-2022
dc.contributor.authorOzkan-Kotiloglu, Selin
dc.contributor.authorKuyucuklu, Gulcan
dc.contributor.authorBaltacioglu, Esra
dc.contributor.authorGuncu, Guliz
dc.contributor.authorDursun, Erhan
dc.contributor.authorSukuroglu, Erkan
dc.contributor.authorKarabulut, Erdem
dc.date.accessioned2024-06-12T11:02:33Z
dc.date.available2024-06-12T11:02:33Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: One of the cytokines involved in periodontal breakdown in periodontitis is; Tumor necrosis factor (TNF), with two types; tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha (LT-alpha). Aim: In the present study, the individual frequency of TNF-alpha -308 promoter, LT-alpha +252 intron, and TNF receptor-2 (TNFR-2) +587 exon polymorphisms associated with chronic (CP) and generalized aggressive periodontitis (GAP) were evaluated in Turkish population. Materials and Methods: This research was conducted on 224 periodontitis patients (P) (119 CP, 105 GAP patients) and 85 healthy controls (C). Blood samples were collected, and specific DNA regions were amplified by PCR method. Investigated gene polymorphisms were determined by RFLP (Restriction Fragment Length Polymorphism). Statistical analyses, including linkage analyses were performed. Results: While there was no statistically significant difference in LT-alpha +252 polymorphisms between the patients and controls, significant associations between TNF-alpha-308 GA genotype and CP and GAP were determined. For TNFR-2 (+587) T/G polymorphism; TT, TG and GG genotype and allele frequencies were analysed and significant differences were found in genotype and allele frequencies between the control and CP and GAP groups (p<0,001). Conclusion: This is the first study investigating the TNF-alpha, LT-alpha and TNFR-2 polymorphisms in CP and GAP in Turkish population. Significant differences were found in genotype and allele frequencies, in CP and GAP groups.en_US
dc.identifier.endpage179en_US
dc.identifier.issn2347-2545
dc.identifier.issn2347-2367
dc.identifier.issue7en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21325
dc.identifier.volume8en_US
dc.identifier.wosWOS:000595155900029en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAmber Publicationen_US
dc.relation.ispartofJournal Of Research In Medical And Dental Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGene Polymorphismsen_US
dc.subjectPeriodontitisen_US
dc.subjectTumor Necrosis Factor Alphaen_US
dc.subjectLymphotoxin Alphaen_US
dc.subjectTumor Necrosis Factor Receptor 2en_US
dc.subjectTumor-Necrosis-Factoren_US
dc.subjectLymphotoxin-Alphaen_US
dc.titleInvestigation of TNF-?, LT-? and TNFR-2 gene Polymorphisms in Patients with Periodontitis in Turkeyen_US
dc.typeArticleen_US

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