Amifostine Treatment of a Patient with Refractory Acute Myeloid Leukemia

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dc.contributor.authorTekgunduz, Emre
dc.contributor.authorErikci, Alev Akyol
dc.contributor.authorOzturk, Ahmet
dc.date.accessioned2024-06-12T10:50:34Z
dc.date.available2024-06-12T10:50:34Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description34th National Hematology Congress -- OCT 08-11, 2008 -- Izmir, TURKEYen_US
dc.description.abstractThe prognosis for the majority of acute myeloid leukemia (AML) patients without a donor is dismal whether conventional salvage chemotherapy regimens or investigational strategies are used, and most of these patients will eventually die of their disease. There is no standard chemotherapy regimen that provides durable complete remission in patients with refractory AML. Beneficial effects of amifostine, either alone or in combination with conventional chemotherapy, was demonstrated in patients with myelodysplastic syndrome and poor prognosis AML. Here we report our second experience with AML patients who were successfully treated with an amifostine containing noncytotoxic drug combination. The beneficial effects of amifostine are not limited to cytoprotectivity which enables dose-escalation for many chemotherapeutic agents, at least in some refractory AML it can also be used as a bridge to hematopoietic stem cell transplantation.en_US
dc.identifier.endpage188en_US
dc.identifier.issn1301-3149
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-70349140558en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage186en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18054
dc.identifier.volume26en_US
dc.identifier.wosWOS:000267718200019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEkin Tibbi Yayincilik Ltd Sti-Ekin Medical Publen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Myeloid Leukemiaen_US
dc.subjectAmifostineen_US
dc.subjectAcute Myelogenous Leukemiaen_US
dc.subjectMyelodysplastic Syndromesen_US
dc.subjectTherapyen_US
dc.titleAmifostine Treatment of a Patient with Refractory Acute Myeloid Leukemiaen_US
dc.typeArticleen_US

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