The Association of Gene Polymorphisms of the Angiotensin-Converting Enzyme and Angiotensin II Receptor Type 1 with Ischemic Stroke in Turkish Subjects of Trakya Region

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dc.authoridbudak, metin/0000-0002-5968-2048
dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.authorwosidBudak, metin/Z-3010-2019
dc.contributor.authorSipahi, Tammam
dc.contributor.authorGuldiken, Baburhan
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorUstundag, Sedat
dc.contributor.authorTurgut, Nilda
dc.contributor.authorBudak, Metin
dc.contributor.authorCakina, Suat
dc.date.accessioned2024-06-12T10:50:19Z
dc.date.available2024-06-12T10:50:19Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to investigate the frequency of ACE insertion/deletion (I/D) and AT1R (A1166C) gene polymorphisms in ischemic stroke patients in Trakya region and the relation between these gene polymorphisms and stroke subtypes and vascular risk factors. Patients and Methods: The study involved 162 patients with ischemic stroke and 146 control subjects. Ischemic stroke patients were divided into large and small vessel disease subgroups according to ORG 10172 in Acute Stroke Treatment TOAST criteria. The ACE I/D polymorphism was investigated using polymerase chain reaction (PCR), and the AT1R (A1166C) polymorphism was identified using PCR and restriction fragment length polymorphism (RFLP) assay. Results: The ACE I/D genotype distribution in patients (DD=34.0%, ID=50.0%, II=16.0%) did not differ from those in controls (DD=34.3%, ID=49.7%, II=16.1%). The AT1R A1166C genotype distribution in patients (AA=58.0%, CA=34.6%, CC=7.4%) did not significantly differ from those in controls (AA=60.1%, CA=35.7%, CC=4.2%). There was also no difference among the stroke subgroups regarding the distribution of ACE I/D and AT1R (A1166C) polymorphisms. Conclusion: Our results show that ACE I/D and AT1R (A1166C) gene polymorphisms were not genetic risk factors for ischemic stroke in subjects in Trakya region.en_US
dc.identifier.endpage8en_US
dc.identifier.issn1301-3149
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17962
dc.identifier.volume26en_US
dc.identifier.wosWOS:000265174300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectACE I/D Gene Polymorphismen_US
dc.subjectAT1R (A1166C) Gene Polymorphismen_US
dc.subjectIschemic Strokeen_US
dc.subjectRenin-Angiotensin Systemen_US
dc.subjectInsertion Deletion Polymorphismen_US
dc.subjectAce I/D Polymorphismen_US
dc.subjectMolecular-Cloningen_US
dc.subjectSystemen_US
dc.subjectRisken_US
dc.subjectSusceptibilityen_US
dc.titleThe Association of Gene Polymorphisms of the Angiotensin-Converting Enzyme and Angiotensin II Receptor Type 1 with Ischemic Stroke in Turkish Subjects of Trakya Regionen_US
dc.typeArticleen_US

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