In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions

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dc.authoridBüyükokuroğlu, Mehmet emin/0000-0002-1452-3879
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridOzdemir, Zafer/0000-0002-8362-3136
dc.authorwosidBüyükokuroğlu, Mehmet emin/GYA-5649-2022
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidOzdemir, Zafer/C-1666-2013
dc.contributor.authorOrtac, Deniz
dc.contributor.authorCemek, Mustafa
dc.contributor.authorKaraca, Turan
dc.contributor.authorBuyukokuroglu, Mehmet E.
dc.contributor.authorOzdemir, Zafer O.
dc.contributor.authorKocaman, Ayse Tuba
dc.contributor.authorGones, Sadik
dc.date.accessioned2024-06-12T11:02:31Z
dc.date.available2024-06-12T11:02:31Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractContext: Okra, Abelmoschus esculentus (L.) (Malvaceae), is a medicinal plant widely used in Turkish traditional medicine for the treatment of various diseases such as ulcers and gastritis. Objective: In the present study, we evaluated the gastroprotective effect of okra against ethanol-induced acute gastric mucosal injury in animal models. Materials and methods: Wistar rats were treated with 500, 250 or 100 mg/kg okra; 20 mg/kg famotidine (Fam); and 75 mg/kg quercetin (Que). Following a 60 min period, all the rats were given 1 mL of ethanol (80%). One hour after the administration of ethanol, all groups were sacrificed. Results: At 5000 mg/kg, the extract produced (okra) no signs of toxicity in animals. Okra 500, 250, 100, Fam 20 and Que 75 inhibited ulcer formation by 81.0, 67.5, 67.0, 76.3 and 72.4%, respectively. Okra 500 significantly decreased edema, hemorrhage and inflammation scores compared with the ethanol group (p < 0.05). The oxidant levels decreased significantly in the all study groups compared within ethanol group (p < 0.001). Serum beta-carotene and retinol levels significantly increased 40.2 and 45.4% in the okra 500 group. In okra 500, 250 and Fam 20 groups, apoptosis significantly decreased (p < 0.001), while okra 500, 250 and Fam 20 groups showed a higher percentage of cell proliferation compared with the ethanol group (p < 0.001). Discussion and conclusions: Our in vivo data indicate that okra has a gastroprotective effect against ethanol and could reduce the gastric ulcer as seen from biochemical and histopathological results. We suggest that okra could be a possible therapeutic antiulcer agent.en_US
dc.description.sponsorshipYildiz Technical University research fund [2015-07-04-KAP02]en_US
dc.description.sponsorshipThis study was supported by grants from the Yildiz Technical University research fund [2015-07-04-KAP02].en_US
dc.identifier.doi10.1080/13880209.2018.1442481
dc.identifier.endpage175en_US
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issue1en_US
dc.identifier.pmid29513129en_US
dc.identifier.scopus2-s2.0-85051635963en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage165en_US
dc.identifier.urihttps://doi.org/10.1080/13880209.2018.1442481
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21305
dc.identifier.volume56en_US
dc.identifier.wosWOS:000426940500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPharmaceutical Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastroprotectionen_US
dc.subjectApoptosisen_US
dc.subjectGastric Ulceren_US
dc.subjectImmunohistochemistryen_US
dc.subjectUlcer Indexen_US
dc.subjectUlcer Inhibitionen_US
dc.subjectNitric-Oxideen_US
dc.subjectAscorbic-Aciden_US
dc.subjectRatsen_US
dc.subjectGlutathioneen_US
dc.subjectInjuryen_US
dc.subjectAntioxidanten_US
dc.subjectQuercetinen_US
dc.subjectExpressionen_US
dc.subjectDamageen_US
dc.subjectOilen_US
dc.titleIn vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesionsen_US
dc.typeArticleen_US

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